2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. 2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan

2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan is a Drug-linker conjugates for ADC consisting of the ADC Cytotoxin Exatecan (HY-13631) and a linker. 2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan

2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan Chemical Structure

CAS No. : 3115661-30-5

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2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan Related Antibodies

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Description

2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan is a Drug-linker conjugates for ADC consisting of the ADC Cytotoxin Exatecan (HY-13631) and a linker. 2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan can be used for synthesis of ADCs[1].

In Vivo

2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan (synthetic ADC-2) (1-10 mg/kg; i.v.; single dose) exhibits potent, selective anti-tumor activity against HER2-positive tumors and drug-resistant tumors in mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1277.44

Formula

C62H84N8O19S
CAS No.
SMILES

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC#CC6=CN=C(S(C)(=O)=O)N=C6OC)=O)=O)=O)=O)=CC7=C1COC([C@]7(O)CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-MSP(4-OMe)-5-HA-PEG8-VA-Exatecan3115661-30-5Drug-Linker Conjugates for ADCTopoisomerase4-methoxy-2-(methylsulfonyl)pyrimidine moietyDS8201-resistant cellsbreast cancerexatecan payloadoctaethylene glycol hydrophilic segmentvaline-alanine peptide triggerHER2-positive cancer cellscolorectal cancergastric cancerantibody-drug conjugatesInhibitorinhibitorinhibit

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