Kat2a - K(lysine) acetyltransferase 2A Gene

Also Known as Gcn5; Gcn5l2; mmGCN5; 1110051E14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14534

About Kat2a

Chromosome 11: 100,595,572-100,603,291 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 209 orthologues, 11 paralogues and is associated with 45 phenotypes. Ubiquitous expression in adrenal adult (RPKM 33.5), ovary adult (RPKM 29.4) and 28 other tissues.

Summary

Enables H3 Histone Acetyltransferase activity; chromatin binding activity; and Histone Acetyltransferase activity (H4-K12 specific). Involved in several processes, including long-term memory; positive regulation of macromolecule metabolic process; and regulation of regulatory T cell differentiation. Acts upstream of or within several processes, including brain development; chordate embryonic development; and histone acetylation. Located in mitotic spindle and nucleus. Part of ATAC complex and SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kat2a Products (2)

mRNA Protein Name
NM_001038010.2 NP_001033099.1 histone acetyltransferase KAT2A isoform b
NM_020004.5 NP_064388.2 histone acetyltransferase KAT2A isoform a

Kat2a Protein Structure

PCAF_N

PCAF_N: pfam06466 (80 - 329)

COG5076

COG5076: cl34891 (483 - 823)

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (723 - 822)

  • 0
  • 200
  • 400
  • 600
  • 829 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase KAT2A

  • GCN5 general control of amino acid synthesis-like 2

  • PCAF-B/GCN5

  • general control of amino acid synthesis 5-like 2

  • general control of amino acid synthesis protein 5-like 2

  • general control of amino acid synthesis, yeast homolog-like 2

  • general control of amino acid synthesis-like 2

  • histone acetyltransferase GCN5

  • histone glutaryltransferase KAT2A

  • histone succinyltransferase KAT2A

  • lysine acetyltransferase 2A

Kat2a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Kat2a Q9JHD2 Trrap Mus musculus Q80YV3
Anti Bait CoIP
20508642
Intra
Kat2a Q9JHD2 Trrap Mus musculus Q80YV3
Pull Down
20946988
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173158 AUR1545 Inhibitor 99.58% Unkown
HY-122822 GSK699 98.80% Unkown
HY-168428 CHI-KAT8i5 98.00% Unkown
HY-RS07074 KAT2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07075 Kat2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181695 PROTAC KAT2A/B degrader-1 Degrader / Unkown
HY-RS07076 Kat2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1122565 KAT2A/B ligand 1 Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kat2a NCBI NCBI:2648