Gclm - glutamate-cysteine ligase, modifier subunit Gene

Also Known as Gcmc; Glclr

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14630

Summary

Enables glutamate-cysteine Ligase catalytic subunit binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and positive regulation of glutamate-cysteine Ligase activity. Part of glutamate-cysteine Ligase complex. Is expressed in several structures, including alimentary system; liver; nervous system; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine Ligase modifier subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclm Products (1)

mRNA Protein Name
NM_008129.4 NP_032155.1 glutamate--cysteine ligase regulatory subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate-cysteine ligase catalytic subunit binding IDA
IDA: Inferred from direct assay
12384496 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12384496 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic mitochondrial changes IGI
IGI: Inferred from genetic interaction
15288121 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within cysteine metabolic process IMP
IMP: Inferred from mutant phenotype
12384496 MGI
acts upstream of or within glutathione biosynthetic process IDA
IDA: Inferred from direct assay
16081425 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: Inferred from mutant phenotype
12384496 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
15288121 MGI
acts upstream of or within positive regulation of glutamate-cysteine ligase activity IDA
IDA: Inferred from direct assay
12384496 MGI
acts upstream of or within regulation of mitochondrial depolarization IGI
IGI: Inferred from genetic interaction
15288121 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
12384496 MGI
Cellular Component GO Annotation Evidence References Source
part of glutamate-cysteine ligase complex IDA
IDA: Inferred from direct assay
12384496 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate--cysteine ligase regulatory subunit

  • GCS light chain

  • gamma-ECS regulatory subunit

  • gamma-glutamylcysteine synthetase regulatory subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W015600 2-Acetamidophenol 99.73% Unkown
HY-171705 KMS99220 99.48% Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% Unkown
HY-121523 MIND4-17 Activator 99.05% Unkown
HY-W015600S 2-Acetamidophenol-d3 99.48% Unkown
HY-172598 SG16 Inhibitor / Unkown
HY-181907 NBE5 / Unkown
HY-RS05334 GCLM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18936 Gclm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25426 Gclm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gclm NCBI NCBI:2730