RBFOX3 - RNA binding fox-1 homolog 3 Gene

Also Known as FOX3; NEUN; FOX-3; HRNBP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 146713

About RBFOX3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,089,345-79,665,571 (from NCBI)

This gene has 14 transcripts (splice variants), 265 orthologues and 2 paralogues. Biased expression in brain (RPKM 11.3), prostate (RPKM 4.9) and 4 other tissues.

Summary

This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

RBFOX3 Products (47)

mRNA	Protein	Name
NM_001082575.3	NP_001076044.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001350451.2	NP_001337380.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001350453.2	NP_001337382.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385804.1	NP_001372733.1	RNA binding protein fox-1 homolog 3 isoform 3
NM_001385805.1	NP_001372734.1	RNA binding protein fox-1 homolog 3 isoform 3
NM_001385806.1	NP_001372735.1	RNA binding protein fox-1 homolog 3 isoform 4
NM_001385807.1	NP_001372736.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385808.1	NP_001372737.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385809.1	NP_001372738.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385810.1	NP_001372739.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385811.1	NP_001372740.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385812.1	NP_001372741.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385813.1	NP_001372742.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385814.1	NP_001372743.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385815.1	NP_001372744.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385816.1	NP_001372745.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385817.1	NP_001372746.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385818.1	NP_001372747.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385819.1	NP_001372748.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385820.1	NP_001372749.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385821.1	NP_001372750.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385822.1	NP_001372751.1	RNA binding protein fox-1 homolog 3 isoform 5
NM_001385823.1	NP_001372752.1	RNA binding protein fox-1 homolog 3 isoform 5
NM_001385824.1	NP_001372753.1	RNA binding protein fox-1 homolog 3 isoform 6
NM_001385825.1	NP_001372754.1	RNA binding protein fox-1 homolog 3 isoform 7
NM_001385826.1	NP_001372755.1	RNA binding protein fox-1 homolog 3 isoform 7
NM_001385827.1	NP_001372756.1	RNA binding protein fox-1 homolog 3 isoform 9
NM_001385828.1	NP_001372757.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385829.1	NP_001372758.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385830.1	NP_001372759.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385831.1	NP_001372760.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385832.1	NP_001372761.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385833.1	NP_001372762.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385834.1	NP_001372763.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385835.1	NP_001372764.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385836.1	NP_001372765.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385837.1	NP_001372766.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385838.1	NP_001372767.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385839.1	NP_001372768.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385840.1	NP_001372769.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385841.1	NP_001372770.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385842.1	NP_001372771.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385843.1	NP_001372772.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385844.1	NP_001372773.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385845.1	NP_001372774.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385846.1	NP_001372775.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385847.1	NP_001372776.1	RNA binding protein fox-1 homolog 3 isoform 8

RBFOX3 Protein Structure

RRM_1

Fox-1_C

0
100
200
312 a.a.

Protein Preferred Names	Protein Names
RNA binding protein fox-1 homolog 3	RNA binding protein, fox-1 homolog 3

RBFOX3 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80241	NeuN Antibody (YA272)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P83783	NeuN Antibody (YA3480)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P83783A	NeuN Antibody (YA3480)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P85858	NeuN Antibody (YA5550)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P86090	NeuN Antibody (YA5782)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy
Gangliocytoma	Ganglioneuroma Gangliocytoma Of Central Nervous System
Occlusion Precerebral Artery	Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries Occlusion And Stenosis Of Precerebral Artery
Carotid Artery Occlusion	Occlusion And Stenosis Of Carotid Artery
Cerebral Artery Occlusion
Central Neurocytoma	Neurocytoma Neurolipocytoma Neurocytoma Central
Dysembryoplastic Neuroepithelial Tumor	Dysembryoplastic Neuroepithelial Tumour Dysembryoplastic Neuroepithelial Neoplasm Dnet
Clear Cell Ependymoma	Cellular Ependymoma
Cerebellar Liponeurocytoma	Lipomatous Medulloblastoma Central Neurocytoma
Spinal Cord Oligodendroglioma	Oligodendroglioma Of Spinal Cord Well Differentiated Spinal Cord Oligodendroglioma
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Hypertryptophanemia	HYPTRP Hypertryptophanemia, Familial Familial Hypertryptophanemia
Focal Epilepsy	Partial Epilepsy Epilepsies, Partial Localisation-Related Epilepsy
Corneal Dystrophy, Fleck	Fleck Corneal Dystrophy Fcd CFD Corneal Fleck Dystrophy Francois-Neetens Speckled Corneal Dystrophy Corneal Dystrophy, Francois-Neetens Speckled Or Flecked Corneal Dystrophy Francois-Neetens Speckled Or Flecked Dystrophy, Corneal, Fleck
Cauda Equina Neoplasm	Tumor Of The Cauda Equina Neoplasm Of Cauda Equina
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Encephalomalacia
Macular Degeneration, Age-Related, 14	Age Related Macular Degeneration 14 ARMD14 Macular Degeneration, Age-Related, 14, Reduced Risk Of Macular Degeneration, Age-Related, Type 14
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Spinocerebellar Ataxia 45	SCA45 Spinocerebellar Ataxia Type 45
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Specific Developmental Disorder
Disease Of Mental Health	Mental Health Mental Disorders
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Intracranial Cavernous Angioma	Intracranial Cavernoma Intracranial Cavernous Hemangioma
Intracranial Structure Hemangioma	Angioma Of Intracranial Structure Hemangioma Of Intracranial Structure Hemangioma Of Intracranial Structures
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Syndromic Intellectual Disability
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS11726	RBFOX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RBFOX3	MGD	MGI:106368
Canis familiaris	RBFOX3	VGNC	VGNC:45400
Bos taurus	RBFOX3	VGNC	VGNC:33779
Felis catus	RBFOX3	VGNC	VGNC:64517
Rattus norvegicus	RBFOX3	RGD	RGD:1560070
Macaca mulatta	RBFOX3	VGNC	VGNC:76550
Others	RBFOX3	NCBI