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Lilrb4a - leukocyte immunoglobulin-like receptor, subfamily B, member 4A Gene

Also Known as HM18; ILT3; gp49; CD85K; Gp49b; LIR-5; Lilrb4

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14728

Summary

Enables Integrin binding activity. Involved in negative regulation of mast cell activation involved in immune response. Acts upstream of or within several processes, including alpha-beta T cell proliferation; cellular response to lipopolysaccharide; and response to nematode. Located in external side of plasma membrane. Is expressed in urinary system. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Apr 2022]

Lilrb4a Products (2)

mRNA	Protein	Name
NM_001291894.1	NP_001278823.1	leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 2
NM_013532.3	NP_038560.1	leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fibronectin binding	IDA IDA: Inferred from direct assay	34089617	MGI
enables integrin binding	IDA IDA: Inferred from direct assay	11323698	MGI
enables phosphatase binding	IPI IPI: Inferred from physical interaction	9973385	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10026201	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	18792399	MGI
acts upstream of or within CD8-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	18792399	MGI
acts upstream of or within blood coagulation	IMP IMP: Inferred from mutant phenotype	14557414	MGI
acts upstream of or within cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	14557414	MGI
acts upstream of or within chemokine production	IMP IMP: Inferred from mutant phenotype	15827966	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	15827966	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	17761953	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	19966208	MGI
involved in negative regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	24935931	MGI
involved in negative regulation of mast cell activation	IMP IMP: Inferred from mutant phenotype	12884301	MGI
involved in negative regulation of mast cell activation involved in immune response	IDA IDA: Inferred from direct assay	8855262	MGI
involved in negative regulation of mast cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	11457897	MGI
involved in negative regulation of mast cell activation involved in immune response	IPI IPI: Inferred from physical interaction	11323698	MGI
involved in negative regulation of monocyte activation	IDA IDA: Inferred from direct assay	34089617	MGI
involved in negative regulation of natural killer cell activation	IDA IDA: Inferred from direct assay	8977169	MGI
involved in negative regulation of plasma cell differentiation	IMP IMP: Inferred from mutant phenotype	24935931	MGI
acts upstream of or within neutrophil homeostasis	IMP IMP: Inferred from mutant phenotype	15827966	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	14557414	MGI
acts upstream of or within response to nematode	IMP IMP: Inferred from mutant phenotype	17761953	MGI
acts upstream of or within response to other organism	IMP IMP: Inferred from mutant phenotype	28883820	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	14557414	MGI
acts upstream of or within type 2 immune response	IMP IMP: Inferred from mutant phenotype	19966208	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	8855262	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	14557414	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
leukocyte immunoglobulin-like receptor subfamily B member 4A leukocyte immunoglobulin-like receptor subfamily B member 4	glycoprotein 49 B leukocyte immunoglobulin-like receptor, subfamily B, member 4 mast cell surface glycoprotein Gp49B

Protein Preferred Names

Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 4A

leukocyte immunoglobulin-like receptor subfamily B member 4

glycoprotein 49 B
leukocyte immunoglobulin-like receptor, subfamily B, member 4
mast cell surface glycoprotein Gp49B

Recombinant Lilrb4a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72518	LILRB4/CD85k/ILT3 Protein, Mouse (HEK293, His)	Q64281 (G24-K238)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75866	LILRB4/CD85k/ILT3 Protein, Mouse (HEK293, Fc)	Q64281 (G24-K238)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07654	LILRB4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23690	Lilrb4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown