Gpr37 - G protein-coupled receptor 37 Gene

Also Known as Pael-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14763

Summary

Enables PDZ domain binding activity. Involved in dendrite development; negative regulation of hydrogen peroxide-induced cell death; and positive regulation of MAPK cascade. Acts upstream of or within dopamine biosynthetic process; locomotion involved in locomotory behavior; and positive regulation of dopamine metabolic process. Located in cell surface. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human GPR37 (G protein-coupled receptor 37). [provided by Alliance of Genome Resources, Apr 2022]

Gpr37 Products (1)

mRNA Protein Name
NM_010338.2 NP_034468.2 prosaposin receptor GPR37 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
25977097 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
23690594 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
25977097 MGI
acts upstream of or within dopamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
15218106 MGI
acts upstream of or within locomotion involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
15218106 MGI
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
23690594 MGI
acts upstream of or within positive regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
15218106 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell surface IMP
IMP: Inferred from mutant phenotype
25977097 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25977097 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prosaposin receptor GPR37

  • parkin-associated endothelin B-like receptor

  • probable G-protein coupled receptor 37

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P1342 Prosaptide Tx14(A) 99.73% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3840 Head activator neuropeptide Activator 99.51% Unkown
HY-P1342A Prosaptide Tx14(A) TFA Activator 99.81% Unkown
HY-RS05709 GPR37 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05710 GPR37L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17660 Gpr37 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24121 Gpr37 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr37 NCBI NCBI:2861