Pdia3 - protein disulfide isomerase associated 3 Gene

Also Known as Erp; PDI; Plca; 58kDa; ERp57; ERp60; ERp61; Grp58; PDI-Q2; PI-PLC; PLC[a]

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14827

About Pdia3

Chromosome 2: 121,244,256-121,269,168 forward strand.GRCm39:CM000995.3

This gene has 4 transcripts (splice variants), 225 orthologues, 13 paralogues and is associated with 10 phenotypes. Ubiquitous expression in placenta adult (RPKM 23.6), ovary adult (RPKM 132.6) and 28 other tissues.

Summary

Predicted to enable several functions, including identical protein binding activity; protein disulfide isomerase activity; and protein-disulfide reductase (glutathione) activity. Acts upstream of or within cellular response to interleukin-7 and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]

Pdia3 Products (1)

mRNA Protein Name
NM_007952.2 NP_031978.2 protein disulfide-isomerase A3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21093319 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to interleukin-7 IDA
IDA: Inferred from direct assay
29581031 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15858817 MGI
acts upstream of or within platelet aggregation IMP
IMP: Inferred from mutant phenotype
28576878 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15858817 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19995400 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9493907 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pdia3 Protein Structure

ER_PDI_fam

ER_PDI_fam: cl36828 (25 - 486)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

protein disulfide-isomerase A3

  • 58 kDa glucose-regulated protein

  • 58 kDa microsomal protein

  • ER protein 57

  • ER protein 60

  • disulfide isomerase ER-60

  • endoplasmic reticulum protein

  • endoplasmic reticulum resident protein 57

  • endoplasmic reticulum resident protein 60

  • glucose regulated protein, 58 kDa

  • p58

  • phospholipase C, alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0177 Diosgenin Inhibitor 99.92% Unkown
HY-100432 LOC14 98.0% Unkown
HY-122895 E64FC26 98.48% Unkown
HY-122895A (E/Z)-E64FC26 99.80% Unkown
HY-RS10266 PDIA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10267 Pdia3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151286 Antitumor agent-73 Inhibitor / Unkown
HY-170655 PDI-IN-4 Inhibitor / Unkown
HY-187198 PDIA1/A3-IN-1 Inhibitor / Unkown
HY-P11857 Alkyne-GRWHPM-CONH-NH-CMK Inhibitor / Unkown
HY-RS10268 Pdia3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdia3 NCBI NCBI:2923