Has2 - hyaluronan synthase 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15117

Summary

Enables hyaluronan synthase activity. Involved in several processes, including circulatory system development; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Acts upstream of or within bone morphogenesis and hyaluronan metabolic process. Located in cytoplasmic vesicle and plasma membrane raft. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skin. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Has2 Products (2)

mRNA Protein Name
NM_008216.3 NP_032242.3 hyaluronan synthase 2
NM_008216.3 NP_032242.3 hyaluronan synthase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hyaluronan synthase activity IDA
IDA: Inferred from direct assay
10455188 MGI
Biological Process GO Annotation Evidence References Source
involved in atrioventricular canal development IMP
IMP: Inferred from mutant phenotype
10930438 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
21246657 MGI
involved in endocardial cushion to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
10930438 MGI
involved in extracellular matrix assembly IDA
IDA: Inferred from direct assay
10455188 MGI
involved in extracellular polysaccharide biosynthetic process IDA
IDA: Inferred from direct assay
10455188 MGI
involved in hyaluronan biosynthetic process IDA
IDA: Inferred from direct assay
8798545 MGI
involved in hyaluronan biosynthetic process IMP
IMP: Inferred from mutant phenotype
10930438 MGI
acts upstream of or within hyaluronan metabolic process IMP
IMP: Inferred from mutant phenotype
21246657 MGI
involved in vasculogenesis IMP
IMP: Inferred from mutant phenotype
10930438 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24057227 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
24057227 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
10455188 MGI
located in plasma membrane raft IDA
IDA: Inferred from direct assay
22383528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hyaluronan synthase 2

  • HA synthase 2

  • hyaluronan synthase homolog

  • hyaluronate synthase 2

  • hyaluronic acid synthase 2

Recombinant Has2 Proteins

Cat. No. Product Name Accession Purity
HY-P72222 HAS2 Protein, Mouse (His) P70312 (E67-L374) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14803 Tasimelteon Agonist 99.16% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-131686 Ganglioside GT1b (bovine) ammonium Activator 98.0% Phase 4

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0008 Orcinol glucoside 98.92% Unkown
HY-P2096 Hexapeptide-11 99.77% Unkown
HY-116973 L 738372 Inhibitor / Unkown
HY-RS06007 HAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14803S Tasimelteon-d5 Agonist / Unkown
HY-RS17492 Has2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23949 Has2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Has2 NCBI NCBI:3037