IGSF11 - immunoglobulin superfamily member 11 Gene

Also Known as CT119; VSIG3; BTIGSF; Igsf13; BT-IgSF; CXADRL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152404

About IGSF11

Cytogenetic location: 3q13.32 Genomic coordinates (GRCh38): 3:118,900,557-119,146,020 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 14 paralogues. Biased expression in testis (RPKM 12.0), brain (RPKM 8.3) and 4 other tissues.

Summary

IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]

IGSF11 Products (11)

mRNA Protein Name
NM_001015887.3 NP_001015887.1 immunoglobulin superfamily member 11 isoform b precursor
NM_001353318.2 NP_001340247.1 immunoglobulin superfamily member 11 isoform c
NM_001353319.2 NP_001340248.1 immunoglobulin superfamily member 11 isoform d
NM_001353320.2 NP_001340249.1 immunoglobulin superfamily member 11 isoform a precursor
NM_001353321.2 NP_001340250.1 immunoglobulin superfamily member 11 isoform e precursor
NM_001353322.2 NP_001340251.1 immunoglobulin superfamily member 11 isoform f precursor
NM_001353323.2 NP_001340252.1 immunoglobulin superfamily member 11 isoform g precursor
NM_001353324.2 NP_001340253.1 immunoglobulin superfamily member 11 isoform h precursor
NM_001353325.2 NP_001340254.1 immunoglobulin superfamily member 11 isoform i
NM_001353326.2 NP_001340255.1 immunoglobulin superfamily member 11 isoform j
NM_152538.4 NP_689751.2 immunoglobulin superfamily member 11 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
26595655 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26595655 GOA
Biological Process GO Annotation Evidence References Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules IMP
IMP: Inferred from mutant phenotype
15795899 GOA
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
26595655 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGSF11 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (24 - 128)

Ig_3

Ig_3: Immunoglobulin domain (150 - 219)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

immunoglobulin superfamily member 11

  • CXADR like 1

Recombinant IGSF11 Proteins

Cat. No. Product Name Accession Purity
HY-P70854 IGSF11 Protein, Human (HEK293, Fc) Q5DX21-1 (L23-G245) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76411 IGSF11 Protein, Human (HEK293, His) AAH34411.1 (E23-G240) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78788 IGSF11 Protein, Human (Biotinylated, Fc-Avi) Q5DX21-1 (L23-G241) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06647 IGSF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19063 Igsf11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25553 Igsf11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IGSF11 VGNC VGNC:53583
Felis catus IGSF11 VGNC VGNC:62895
Mus musculus IGSF11 MGD MGI:2388477
Canis familiaris IGSF11 VGNC VGNC:53077
Macaca mulatta IGSF11 VGNC VGNC:73608
Rattus norvegicus IGSF11 RGD RGD:1308758
Others IGSF11 NCBI