Hsd11b1 - hydroxysteroid 11-beta dehydrogenase 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15483

Summary

Enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. Acts upstream of or within lung development. Predicted to be located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study cortisone reductase deficiency 2. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 2; and obesity. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsd11b1 Products (2)

mRNA Protein Name
NM_001044751.1 NP_001038216.1 11-beta-hydroxysteroid dehydrogenase 1
NM_008288.2 NP_032314.2 11-beta-hydroxysteroid dehydrogenase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
8940387 MGI
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IMP
IMP: Inferred from mutant phenotype
12439781 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12439781 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

11-beta-hydroxysteroid dehydrogenase 1

corticosteroid 11-beta-dehydrogenase isozyme 1

  • 11-DH

  • 11-beta-HSD1

  • 11-beta-HSD1A/MCR

  • 11-beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase

  • 11beta-HSD-1

  • 11beta-HSD1A

  • 11beta-hydroxysteroid dehydrogenase type 1

  • 7-oxosteroid reductase

  • Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-167696 11β-HSD1-IN-16 Inhibitor 99.03% Unkown
HY-RS06387 HSD11B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20631 Hsd11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27140 Hsd11b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd11b1 NCBI NCBI:3290