Hsd17b1 - hydroxysteroid (17-beta) dehydrogenase 1 Gene

Also Known as E2DH; 17HSDB1; Hsd17ba; 17beta-HSD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15485

Summary

Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity and testosterone dehydrogenase [NAD(P)] activity. Involved in estrogen biosynthetic process and testosterone biosynthetic process. Predicted to be located in cytosol. Is expressed in several structures, including adrenal gland; genitourinary system; spleen; submandibular gland; and trachea. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsd17b1 Products (1)

mRNA Protein Name
NM_010475.2 NP_034605.1 17-beta-hydroxysteroid dehydrogenase type 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
9658408 MGI
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
9658408 MGI
enables testosterone dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
9658408 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
29180785 MGI
involved in estrogen biosynthetic process IDA
IDA: Inferred from direct assay
9658408 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
29180785 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
29180785 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
29180785 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
29180785 MGI
involved in testosterone biosynthetic process IDA
IDA: Inferred from direct assay
9658408 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

17-beta-hydroxysteroid dehydrogenase type 1

estradiol 17-beta-dehydrogenase 1

  • 17-beta-HSD 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-159525 Linustedastatum Inhibitor 98.10% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-129583 Lepidiline A Activator 99.54% Unkown
HY-RS06389 HSD17B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19278 Hsd17b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25768 Hsd17b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsd17b1 NCBI NCBI:3292