Hsp90aa1 - heat shock protein 90, alpha (cytosolic), class A member 1 Gene

Also Known as hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15519

About Hsp90aa1

Chromosome 12: 110,657,039-110,669,162 reverse strand.GRCm39:CM001005.3

This gene has 8 transcripts (splice variants), 277 orthologues, 3 paralogues and is associated with 36 phenotypes. Broad expression in placenta adult (RPKM 235.9), CNS E11.5 (RPKM 213.3) and 19 other tissues.

Summary

Enables identical protein binding activity; nitric-oxide synthase regulator activity; and protein folding chaperone. Involved in several processes, including axonogenesis; positive regulation of nitrogen compound metabolic process; and positive regulation of protein kinase B signaling. Located in several cellular components, including growth cone; neuronal cell body; and ruffle membrane. Part of protein-containing complex. Is expressed in several structures, including 1st branchial arch; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsp90aa1 Products (1)

mRNA Protein Name
NM_010480.5 NP_034610.1 heat shock protein HSP 90-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12885400 MGI
enables nitric-oxide synthase regulator activity IDA
IDA: Inferred from direct assay
12855682 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12855682 MGI
enables protein folding chaperone IMP
IMP: Inferred from mutant phenotype
24286867 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to heat IMP
IMP: Inferred from mutant phenotype
27496612 MGI
involved in positive regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
12855682 MGI
involved in protein folding IMP
IMP: Inferred from mutant phenotype
27496612 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
24286867 MGI
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
24286867 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17908927 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17923681 MGI
located in dendritic growth cone IDA
IDA: Inferred from direct assay
24286867 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
9122205 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
24286867 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24286867 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
27496612 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hsp90aa1 Protein Structure

PRK14083

PRK14083: cl42520 (17 - 732)

  • 0
  • 200
  • 400
  • 600
  • 733 a.a.
Protein Preferred Names Protein Names

heat shock protein HSP 90-alpha

  • HSP 86

  • HSP86

  • TSTA

  • heat shock 86 kDa

  • heat shock protein 1, alpha

  • heat shock protein 90kDa alpha (cytosolic), class A member 1

  • heat shock protein, 1

  • heat shock protein, 86 kDa 1

  • heat shock protein, 89 kDa

  • tumor-specific transplantation 86 kDa antigen

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N5074 Terrestrosin D 99.30% Unkown
HY-RS06415 HSP90AA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183319 Anticancer agent 320 / Unkown
HY-183760 AChE/BChE-IN-37 Inhibitor / Unkown
HY-RS06416 Hsp90aa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06417 Hsp90aa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N10379 19-epi-Scholaricine 99.14% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsp90aa1 NCBI NCBI:3320