Hspa9 - heat shock protein 9 Gene

Also Known as Csa; Mot2; 74kDa; Grp75; Hsc74; Hsp74; Mot-2; Pbp74; Hsp74a; Hspa9a; Mthsp70; Mortalin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15526

Summary

Enables enzyme binding activity. Involved in iron-sulfur cluster assembly; negative regulation of hematopoietic stem cell differentiation; and negative regulation of hemopoiesis. Acts upstream of or within protein export from nucleus. Located in mitochondrial matrix. Is expressed in blastocyst-stage conceptus; early embryo; germ cell of gonad; heart; and liver. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (HSP70) member 9). [provided by Alliance of Genome Resources, Apr 2022]

Hspa9 Products (1)

mRNA Protein Name
NM_010481.2 NP_034611.2 stress-70 protein, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
12646231 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11900485 MGI
Biological Process GO Annotation Evidence References Source
involved in iron-sulfur cluster assembly IMP
IMP: Inferred from mutant phenotype
26702583 MGI
involved in negative regulation of hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
21123823 MGI
involved in negative regulation of hemopoiesis IMP
IMP: Inferred from mutant phenotype
21123823 MGI
acts upstream of or within protein export from nucleus IDA
IDA: Inferred from direct assay
11900485 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
29913563 MGI
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
11092755 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12931191 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

stress-70 protein, mitochondrial

  • 75 kDa glucose-regulated protein

  • C3H-specific antigen

  • GRP-75

  • heat shock 70 kDa protein 9

  • heat shock protein 9A

  • heat shock protein cognate 74

  • heat shock protein, 74 kDa, A

  • heat shock protein, A

  • p66 MOT

  • peptide-binding protein 74

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152153 GRP78-IN-3 Inhibitor 99.88% Unkown
HY-RS06437 HSPA9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18519 Hspa9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25001 Hspa9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa9 NCBI NCBI:3313