Htr7 - 5-hydroxytryptamine (serotonin) receptor 7 Gene

Also Known as 5-HT7; 5-HT-X

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15566

About Htr7

Chromosome 19: 35,936,134-36,034,907 reverse strand.GRCm39:CM001012.3

This gene has 6 transcripts (splice variants), 221 orthologues, 9 paralogues and is associated with 12 phenotypes. Biased expression in CNS E18 (RPKM 2.3), cortex adult (RPKM 1.5) and 8 other tissues.

Summary

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; immune system; and reproductive system. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Htr7 Products (6)

mRNA Protein Name
NM_008315.3 NP_032341.2 5-hydroxytryptamine receptor 7 isoform 1
NM_001347442.2 NP_001334371.1 5-hydroxytryptamine receptor 7 isoform 2
NM_001360298.1 NP_001347227.1 5-hydroxytryptamine receptor 7 isoform 5 precursor
NM_001360297.1 NP_001347226.1 5-hydroxytryptamine receptor 7 isoform 4 precursor
NM_001360300.1 NP_001347229.1 5-hydroxytryptamine receptor 7 isoform 5 precursor
NM_001360318.1 NP_001347247.1 5-hydroxytryptamine receptor 7 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
8394987 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr7 Protein Structure

7tmA_5-HT7

7tmA_5-HT7: cd15329 (99 - 397)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (118 - 144)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (157 - 187)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (199 - 221)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (238 - 267)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (322 - 352)

7tmA_5-HT7

7tmA_5-HT7: cd15329 (365 - 390)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 7

  • serotonin receptor 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06483 HTR7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06484 Htr7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06485 HTR7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr7 NCBI NCBI:3363