Elavl1 - ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) Gene

Also Known as HUR; Hua; 2410055N02Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15568

Summary

Enables long noncoding RNA binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in posttranscriptional regulation of gene expression; protein import into nucleus; and regulation of stem cell population maintenance. Acts upstream of or within positive regulation of translation. Located in several cellular components, including cytoplasmic stress granule; glutamatergic synapse; and postsynapse. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Elavl1 Products (1)

mRNA	Protein	Name
NM_010485.3	NP_034615.2	ELAV-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lncRNA binding	IDA IDA: Inferred from direct assay	33262333	MGI
enables lncRNA binding	IPI IPI: Inferred from physical interaction	28763438	MGI
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	17288565	MGI
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	24394384	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	17288565	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17475777	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	27616329	MGI
involved in lncRNA-mediated post-transcriptional gene silencing	IMP IMP: Inferred from mutant phenotype	22841487	MGI
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	27609837	MGI
acts upstream of or within mRNA stabilization	IMP IMP: Inferred from mutant phenotype	14976220	MGI
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	24394384	MGI
acts upstream of or within positive regulation of translation	IDA IDA: Inferred from direct assay	21613615	MGI
acts upstream of or within positive regulation of translation	IMP IMP: Inferred from mutant phenotype	21613615	MGI
involved in post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	28350193	MGI
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	27609837	MGI
involved in regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	24394384	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17288565	MGI
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	27430620	MGI
is active in cytoplasmic vesicle	IPI IPI: Inferred from physical interaction	29563620	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	27609837	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26554012	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	26554012	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16168373	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	26554012	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	26554012	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17971298	MGI
located in sarcoplasm	IDA IDA: Inferred from direct assay	17475777	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ELAV-like protein 1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) HU-antigen A elav-like generic protein hu-antigen R melG

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100685	MS-444		99.42%	Unkown
HY-RS04294	ELAVL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18308	Elavl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24786	Elavl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Elavl1	NCBI	NCBI:1994