RASEF - RAS and EF-hand domain containing Gene

Also Known as TSG; RAB45

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 158158

About RASEF

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:82,979,590-83,219,224 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 68 paralogues. Broad expression in stomach (RPKM 15.4), thyroid (RPKM 14.0) and 15 other tissues.

Summary

This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]

RASEF Products (1)

mRNA Protein Name
NM_152573.4 NP_689786.2 ras and EF-hand domain-containing protein

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IMP
IMP: Inferred from mutant phenotype
17448446 GOA
enables GTP binding IMP
IMP: Inferred from mutant phenotype
22399288 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17448446 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IMP
IMP: Inferred from mutant phenotype
17448446 GOA
located in perinuclear region of cytoplasm IMP
IMP: Inferred from mutant phenotype
17448446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASEF Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (12 - 69)

Ras

Ras: Ras family (543 - 709)

  • 0
  • 200
  • 400
  • 600
  • 740 a.a.
Protein Preferred Names Protein Names

ras and EF-hand domain-containing protein

  • ras-related protein Rab-45

RASEF Antibodies

Cat. No. Product Name Application Reactivity
HY-P82047 Rab45 Antibody (YA1792) WB, ICC/IF Human, Mouse
HY-P82047A Rab45 Antibody (YA1792)(PBS only) WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Cutaneous Adenocystic Carcinoma

  • Adenoid Cystic Eccrine Carcinoma

  • Adenoid Cystic Carcinoma Of The Skin

  • Adenoid Cystic Eccrine Carcinoma Of Skin
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11687 RASEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RASEF RGD RGD:1306418
Canis familiaris RASEF VGNC VGNC:45366
Bos taurus RASEF VGNC VGNC:33742
Macaca mulatta RASEF VGNC VGNC:82089
Felis catus RASEF VGNC VGNC:64499
Mus musculus RASEF MGD MGI:2448565
Others RASEF NCBI