Rab45 Antibody (YA1792)
(Synonyms: Ras-related protein Rab-45)Rab45 Antibody (YA1792) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rab45.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 |
Product Details
Rab45 Antibody (YA1792) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rab45.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 83 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 83 kDa
Entrez Gene: 158158 Human ; 242505 Mouse ;
SwissProt: Q8IZ41 Human ; Q5RI75 Mouse ;
OMIM: 611344 Human
A synthetic peptide of human RAB45 aa97-110.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Rab45 binds predominantly GDP, and also GTP. Acts as a dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules[1][2].
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Subcellular Localization
Cytoplasm, perinuclear region
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Expression
Tissue_specificity:Down-regulated in cutaneous melanoma cells but not in breast cancer cells -
Isoforms & Post-Translational Modification
Q8IZ41 has 2 isomers: Q8IZ41-1: 82879 Da (predicted); Q8IZ41-2: 20736 Da (predicted).
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Subunit
Homodimer (PubMed:17448446). Interacts with the dynein-dynactin complex (PubMed:30814157)
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SwissProt ID
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Synonyms
Ras-related protein Rab-45
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Research Field
Signal Transduction
Documentation
[1]. Shintani M, et al. Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. Biochem Biophys Res Commun. 2007 Jun 8;357(3):661-7. [Content Brief]
[2]. Wang Y, et al. CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic. J Cell Biol. 2019 May 6;218(5):1619-1633. [Content Brief]
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