Id1 - inhibitor of DNA binding 1, HLH protein Gene

Also Known as Idb1; bHLHb24; D2Wsu140e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15901

Summary

Enables protein self-association and transcription regulator inhibitor activity. Involved in negative regulation of cold-induced thermogenesis; negative regulation of transcription, DNA-templated; and positive regulation of gene expression. Acts upstream of or within several processes, including endothelial cell morphogenesis; lung development; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ID1 (inhibitor of DNA binding 1, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]

Id1 Products (3)

mRNA Protein Name
NM_001355113.1 NP_001342042.1 DNA-binding protein inhibitor ID-1 isoform 1
NM_001369018.1 NP_001355947.1 DNA-binding protein inhibitor ID-1 isoform 3
NM_010495.3 NP_034625.1 DNA-binding protein inhibitor ID-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
1922066 MGI
enables transcription regulator inhibitor activity IDA
IDA: Inferred from direct assay
17681138 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
15820682 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
17717145 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19217292 MGI
acts upstream of or within collagen metabolic process IMP
IMP: Inferred from mutant phenotype
17717145 MGI
acts upstream of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17717145 MGI
acts upstream of or within endothelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
17717145 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
15472070 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
17717145 MGI
acts upstream of or within lung vasculature development IMP
IMP: Inferred from mutant phenotype
17717145 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: Inferred from direct assay
1922066 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19217292 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28270523 MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17717145 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20231428 MGI
acts upstream of or within negative regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
15161906 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12498716 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19217292 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
17681138 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
17681138 MGI
acts upstream of or within protein destabilization IDA
IDA: Inferred from direct assay
15322112 MGI
acts upstream of or within protein destabilization IGI
IGI: Inferred from genetic interaction
15322112 MGI
acts upstream of or within regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
17717145 MGI
acts upstream of or within regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
12498716 MGI
acts upstream of or within response to antibiotic IMP
IMP: Inferred from mutant phenotype
17717145 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9418957 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15322112 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-binding protein inhibitor ID-1

  • inhibitor of differentiation 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124697 BMP signaling agonist sb4 Agonist 99.98% Unkown
HY-129241 AGX51 Antagonist 99.33% Unkown
HY-80012 SJB3-019A Inhibitor 99.88% Unkown
HY-110245 DMH2 Inducer 99.84% Unkown
HY-RS06522 ID1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06528 Idh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N20711 Usenamine A / Unkown
HY-114802 O-1663 / Unkown
HY-RS16689 Id1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23124 Id1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Id1 NCBI NCBI:3397