Il1r2 - interleukin 1 receptor, type II Gene

Also Known as CD121b; Il1r-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16178

Summary

Enables interleukin-1 binding activity and interleukin-1 receptor activity. Acts upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm. Is expressed in several structures, including dorsal aorta; gut; pituitary gland; reproductive system; and thymus. Human ortholog(s) of this gene implicated in aggressive periodontitis. Orthologous to human IL1R2 (interleukin 1 receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Il1r2 Products (3)

mRNA Protein Name
NM_001360800.1 NP_001347729.1 interleukin-1 receptor type 2 isoform 1 precursor
NM_001360801.1 NP_001347730.1 interleukin-1 receptor type 2 isoform 3
NM_010555.5 NP_034685.1 interleukin-1 receptor type 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-1 binding IPI
IPI: Inferred from physical interaction
23395675 MGI
enables interleukin-1 receptor activity IPI
IPI: Inferred from physical interaction
23395675 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
23395675 MGI
acts upstream of or within negative regulation of interleukin-1 alpha production IMP
IMP: Inferred from mutant phenotype
23395675 MGI
acts upstream of or within negative regulation of interleukin-1-mediated signaling pathway IPI
IPI: Inferred from physical interaction
23395675 MGI
acts upstream of or within negative regulation of protein processing IMP
IMP: Inferred from mutant phenotype
23395675 MGI
acts upstream of protein processing IMP
IMP: Inferred from mutant phenotype
23395675 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23395675 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor type 2

  • CD121 antigen-like family member B

  • IL-1 receptor beta chain

  • IL-1 type II receptor

  • IL-1R-2

  • IL-1R-beta

  • IL-1RT-2

  • IL-1RT2

  • interleukin-1 receptor beta

Recombinant Il1r2 Proteins

Cat. No. Product Name Accession Purity
HY-P72568 IL-1R2 Protein, Mouse (HEK293, His) P27931 (F14-E355) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74820 IL-1R2 Protein, Mouse (HEK293, hFc) P27931 (F14-E355) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171657 4'-Acetoxy resveratrol 99.90% Unkown
HY-RS06721 IL1R2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19694 Il1r2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26189 Il1r2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1r2 NCBI NCBI:7850