Il1rn - interleukin 1 receptor antagonist Gene

Also Known as IL-1ra; F630041P17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16181

Summary

Predicted to enable cytokine receptor binding activity. Acts upstream of or within Insulin secretion and lipid metabolic process. Located in extracellular region and vesicle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Il1rn Products (3)

mRNA Protein Name
NM_001039701.3 NP_001034790.1 interleukin-1 receptor antagonist protein isoform 2 precursor
NM_001159562.1 NP_001153034.1 interleukin-1 receptor antagonist protein isoform 3
NM_031167.5 NP_112444.1 interleukin-1 receptor antagonist protein isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within insulin secretion IMP
IMP: Inferred from mutant phenotype
12975454 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
12975454 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
15240711 MGI
located in vesicle IDA
IDA: Inferred from direct assay
15240711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor antagonist protein

  • IL-1RN

  • IL1 inhibitor

  • IRAP

Recombinant Il1rn Proteins

Cat. No. Product Name Accession Purity
HY-P72566 IL-1RA/IL-1RN Protein, Mouse P25085-1 (R27-Q178) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700197AF Animal-Free IL-1RA/IL-1RN Protein, Mouse (His) P25085-1 (R27-Q178) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06727 IL1RN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17664 Il1rn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24125 Il1rn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1rn NCBI NCBI:3557