Il18r1 - interleukin 18 receptor 1 Gene

Also Known as Il1rrp; Il18ralpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16182

Summary

Enables interleukin-18 receptor activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of interleukin-18 receptor complex. Is expressed in dorsal aorta; gonad; mesonephros; and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Il18r1 Products (3)

mRNA Protein Name
NM_001161842.1 NP_001155314.1 interleukin-18 receptor 1 isoform b precursor
NM_001161843.1 NP_001155315.1 interleukin-18 receptor 1 isoform b precursor
NM_008365.2 NP_032391.1 interleukin-18 receptor 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables interleukin-18 receptor activity IMP
IMP: Inferred from mutant phenotype
10227969 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26099046 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T-helper 1 cell differentiation IMP
IMP: Inferred from mutant phenotype
10227969 MGI
acts upstream of or within interleukin-18-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
10227969 MGI
acts upstream of or within natural killer cell activation IMP
IMP: Inferred from mutant phenotype
10227969 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26656097 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
10227969 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
10227969 MGI
acts upstream of type II interferon production IMP
IMP: Inferred from mutant phenotype
10227969 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-18 receptor 1

  • CD218 antigen-like family member A

  • IL-18R-1

  • IL-18R-alpha

  • IL-18R1

  • IL-18Ralpha

  • IL-1Rrp

  • IL1 receptor-related protein

  • IL1R-rp

  • interleukin 1 receptor related protein

  • interleukin-18 receptor alpha

Recombinant Il18r1 Proteins

Cat. No. Product Name Accession Purity
HY-P75845 IL-18R alpha Protein, Mouse (HEK293, Fc) Q61098 (K20-G326) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75846 IL-18R alpha Protein, Mouse (HEK293, His-Fc) Q61098 (K20-G326) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75847 IL-18R alpha Protein, Mouse (HEK293, His) Q61098/NP_032391.1 (K20-G326) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06710 IL18R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174630 Human IL18R1 mRNA / Unkown
HY-RS19262 Il18r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25751 Il18r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il18r1 NCBI NCBI:8809