Il2rg - interleukin 2 receptor, gamma chain Gene

Also Known as gc; p64; [g]c; CD132; gamma(c)

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16186

Summary

This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Il2rg Products (2)

mRNA	Protein	Name
NM_001308535.1	NP_001295464.1	cytokine receptor common subunit gamma isoform b precursor
NM_013563.4	NP_038591.1	cytokine receptor common subunit gamma isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-2 binding	IPI IPI: Inferred from physical interaction	8262055	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of B cell differentiation	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	23918385	MGI
acts upstream of mature B cell differentiation	IMP IMP: Inferred from mutant phenotype	23918385	MGI
acts upstream of or within positive regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of or within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within positive regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	9916699	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8262055	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytokine receptor common subunit gamma	IL-2 receptor subunit gamma IL-2R subunit gamma common gamma chain gamma C receptor interleukin-2 receptor subunit gamma

Recombinant Il2rg Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70693	IL-2R gamma/CD132 Protein, Mouse (HEK293, His)	Q3UPA9 (S25-A263)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74807	IL-2R gamma/CD132 Protein, Mouse (HEK293, His-Fc)	P34902/NP_038591.1 (W23-A263)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991201	REGN-7257	Inhibitor	95.34%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06750	IL2RG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20039	Il2rg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26542	Il2rg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il2rg	NCBI	NCBI:3561