Impact - impact, RWD domain protein Gene

Also Known as E430016J11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16210

Summary

Enables actin binding activity and ribosome binding activity. Involved in several processes, including GCN2-mediated signaling; cellular response to starvation; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within negative regulation of protein phosphorylation and regulation of translational initiation. Part of polysome. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Apr 2022]

Impact Products (4)

mRNA Protein Name
NM_001357396.1 NP_001344325.1 protein IMPACT isoform 2
NM_008378.3 NP_032404.1 protein IMPACT isoform 1
NM_001357396.1 NP_001344325.1 protein IMPACT isoform 2
NM_008378.3 NP_032404.1 protein IMPACT isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
22404850 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15937339 MGI
enables protein sequestering activity IDA
IDA: Inferred from direct assay
24333428 MGI
enables ribosome binding IDA
IDA: Inferred from direct assay
22404850 MGI
Biological Process GO Annotation Evidence References Source
involved in GCN2-mediated signaling IMP
IMP: Inferred from mutant phenotype
23447528 MGI
involved in cellular response to amino acid starvation IDA
IDA: Inferred from direct assay
24333428 MGI
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
24333428 MGI
acts upstream of or within negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15937339 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23447528 MGI
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
23447528 MGI
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
23447528 MGI
involved in regulation of cytoplasmic translational initiation in response to stress IDA
IDA: Inferred from direct assay
24333428 MGI
acts upstream of or within regulation of translational initiation IDA
IDA: Inferred from direct assay
15937339 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23447528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein IMPACT

  • imprinted and ancient gene protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2122 Maltitol 98.0% Unkown
HY-B2122R Maltitol (Standard) 96.15% Unkown

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99359 Elezanumab Inhibitor 99.91% Phase 2

Pre-clinical Phase

Bioactive Molecules (74)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0882 Hydroxylamine hydrochloride Inhibitor 99.9% Unkown
HY-B0990 Thiostrepton Inhibitor 99.80% Unkown
HY-W034953 Bathocuproine disulfonate disodium 99.53% Unkown
HY-153306 Zovegalisib Inhibitor 98.80% Unkown
HY-W013706 Inosine-5'-triphosphate trisodium salt 99.09% Unkown
HY-131697 FeTPPS Inhibitor 99.9% Unkown
HY-159062 Goji Extract Activator / Unkown
HY-W012848 1-Phenylethanamine 99.14% Unkown
HY-N0123 Aloin-A 99.31% Unkown
HY-163707 UR778Br Inducer 99.33% Unkown
HY-N0507 Rosavin Inhibitor 99.91% Unkown
HY-N2500 Deoxypodophyllotoxin 99.86% Unkown
HY-B1839 Fluazinam 99.51% Unkown
HY-170620 PARP1 PROTAC 180055 Inhibitor 98.90% Unkown
HY-112749 ME-344 99.80% Unkown
HY-33914 4-Hydroxymethylpyrazole 99.74% Unkown
HY-P3688A β-Amyloid (1-38) TFA 99.38% Unkown
HY-137910 Tembotrione Inhibitor 99.41% Unkown
HY-136528 RA-9 98.57% Unkown
HY-148384 UHMCP1 99.68% Unkown
HY-Y0882S1 Hydroxylamine-d3 hydrochloride 99% Unkown
HY-W035599 Ir[p-F(t-Bu)-ppy]3 / Unkown
HY-114395A (R)-NVS-ZP7-4 98.80% Unkown
HY-124693 DB1055 Inducer / Unkown
HY-143226 DK1 Modulator 99.69% Unkown
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-B0439S1 Sulfadoxine D3 Inhibitor 98.0% Unkown
HY-N0123R Aloin-A (Standard) 98.52% Unkown
HY-P3688 β-Amyloid (1-38) / Unkown
HY-W250147 Basic blue 26 92.33% Unkown
HY-181293 PROTAC AAK1 degrader-1 Degrader / Unkown
HY-W115741S 1-Phenylethanamine-d3 / Unkown
HY-109006 Ilmetropium iodide Inhibitor / Unkown
HY-109036A (S)-Landipirdine / Unkown
HY-111259 Ro 31-1118 free base / Unkown
HY-113958 Difethialone Inhibitor 99.84% Unkown
HY-113958S Difethialone-d4 / Unkown
HY-113958S1 Difethialone-d4-1 Inhibitor / Unkown
HY-117119 VER-3323 Agonist / Unkown
HY-117467 BMT-108908 / Unkown
HY-121299 m-Chlorophenylbiguanide ≥90.0% Unkown
HY-121700 L-751788 Inhibitor / Unkown
HY-125958 AA9 Inhibitor / Unkown
HY-139898 S7958 Antagonist / Unkown
HY-148384A UHMCP1 dihydrochloride Inhibitor / Unkown
HY-14998 Halofenate / Unkown
HY-155237 LIN28-IN-1 Inhibitor / Unkown
HY-156283 Antibacterial agent 159 / Unkown
HY-158220C Hyaluronic acid methacryloyl (MW 50000) / Unkown
HY-160685 GW809897X Inhibitor / Unkown
HY-160708 Tie2 kinase inhibitor 3 Inhibitor / Unkown
HY-161577 BFC1103 / Unkown
HY-163736 mPGES-1/5-LOX-IN-1 Inhibitor / Unkown
HY-178174 MGB4 Inhibitor / Unkown
HY-178176 PROTAC CB1R Degrader-1 / Unkown
HY-178497 ZJK-807 / Unkown
HY-178937 Anticancer agent 284 Inhibitor / Unkown
HY-179265 D-CAM-14 Inhibitor / Unkown
HY-185122 MS6178 Activator / Unkown
HY-B0357B Diclazuril sodium Inhibitor / Unkown
HY-RS06797 IMPACT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W250169 Secondary alcohol polyoxyethylene ether / Unkown
HY-W587768 Metoxadiazone 99.08% Unkown
HY-Y0882S Hydroxylamine-15N hydrochloride / Unkown
HY-127098 Kahweol linoleate / Unkown
HY-164469 CHMFL-48 Inhibitor / Unkown
HY-170974 SDH-IN-20 Inhibitor / Unkown
HY-184610 Selenium nanoparticles / Unkown
HY-B0824A (1R)-cis-Bifenthrin / Unkown
HY-RS21873 Impact Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28390 Impact Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W114420 3-Methyl-L-tyrosine / Unkown
HY-W158160 AGS1286 sodium Inhibitor / Unkown
HY-W727209 Fluazaindolizine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Impact NCBI NCBI:55364