mPGES-1/5-LOX-IN-1
mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact.
For research use only. We do not sell to patients.
- Formula: C20H22N4O6S
- Molecular Weight:446.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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5-LOX 1.89 μM (IC50) |
mPGES-1 0.92 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:rat[1]
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Dosage:10 mg/kg
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Administration:P.o.
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Result:Showed anti-inflammatory impact and inhibited serum concentrations of PGE2, TNF-α and IL-6, did not generate ulceration in the isolated rat stomach.
Chemical Information
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Molecular Weight 446.48
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Formula C20H22N4O6S
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SMILES
O=C(C1=C(C)NC(NC1C2=CC=C(OC)C(OC)=C2)=O)NC3=CC=C(S(=O)(N)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
mPGES-1/5-LOX-IN-1 Related Classifications
HY-163736 Related Classifications
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