Itpr2 - inositol 1,4,5-triphosphate receptor 2 Gene

Also Known as Ip3r2; Itpr5; insP3R2; InsP3R-2; InsP3R-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16439

Summary

Enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in cellular response to cAMP. Acts upstream of or within calcium ion transport and cellular response to ethanol. Located in cell cortex and sarcoplasmic reticulum. Is expressed in several structures, including heart; liver; medulla oblongata; skeletal muscle; and spleen. Used to study isolated anhidrosis with normal sweat glands. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Itpr2 Products (2)

mRNA Protein Name
NM_010586.2 NP_034716.1 inositol 1,4,5-trisphosphate receptor type 2 isoform 2
NM_019923.4 NP_064307.2 inositol 1,4,5-trisphosphate receptor type 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
IDA: Inferred from direct assay
8063813 MGI
enables intracellularly gated calcium channel activity IDA
IDA: Inferred from direct assay
8063813 MGI
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
8063813 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21424589 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
8063813 MGI
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
20189985 MGI
acts upstream of or within cellular response to ethanol IMP
IMP: Inferred from mutant phenotype
21436055 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
9858485 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9858485 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15632133 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
16014380 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol 1,4,5-trisphosphate receptor type 2

  • IP3 receptor

  • IP3R 2

  • inositol 1,4,5-triphosphate receptor 5

  • inositol 1,4,5-trisphosphate type V receptor

  • inositol trisphosphate receptor type 2

  • type 2 InsP3 receptor

  • type 2 inositol 1,4,5-trisphosphate receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06992 ITPR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20971 Itpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27488 Itpr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itpr2 NCBI NCBI:3709