WBP2NL - WBP2 N-terminal like Gene

Also Known as PAWP; GRAMD7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 164684

About WBP2NL

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,998,788-42,058,371 (from NCBI)

This gene has 10 transcripts (splice variants), 87 orthologues and 1 paralogue. Biased expression in testis (RPKM 7.0) and thyroid (RPKM 0.3).

Summary

WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008]

WBP2NL Products (1)

mRNA Protein Name
NM_152613.3 NP_689826.2 postacrosomal sheath WW domain-binding protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
26116451 GOA
Cellular Component GO Annotation Evidence References Source
located in sperm flagellum IDA
IDA: Inferred from direct assay
26116451 GOA
located in sperm head IDA
IDA: Inferred from direct assay
26116451 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WBP2NL Protein Structure

GRAM

GRAM: GRAM domain (16 - 83)

(103 - 221)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

postacrosomal sheath WW domain-binding protein

  • WW domain-binding protein 2-like

WBP2NL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WBP2NL Q6ICG8 FMR1 Homo sapiens Q8IXW7
Y2H Prey Pooling
32296183
Intra
WBP2NL Q6ICG8 FMR1 Homo sapiens Q8IXW7
Y2H Array
32296183
Intra
WBP2NL Q6ICG8 FMR1 Homo sapiens Q8IXW7
Validated Y2H
32296183
Intra
WBP2NL Q6ICG8 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
WBP2NL Q6ICG8 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
WBP2NL Q6ICG8 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 9

  • Male Infertility Due To Globozoospermia

  • SPGF9

  • Male Infertility Due To Round-Headed Spermatozoa

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Globozoospermia

  • Globozoospermia Syndrome

  • Round-Headed Sperm Syndrome

  • Globozoospermia Complete

  • Globozoospermia Total
Constrictive Pericarditis

  • Pericarditis, Constrictive

  • Pericarditis Constrictive

  • Pericarditis Calculosa

  • Hutinel-Pick Syndrome

  • Chronic Tamponade

  • Chronic Pericardial Constriction

  • Pick Syndrome Of Heart

  • Pick Disease Of Heart

  • Concretio Cordis

  • Calcareous Pericarditis
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS15751 WBP2NL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus WBP2NL VGNC VGNC:67008
Rattus norvegicus WBP2NL RGD RGD:1586458
Macaca mulatta WBP2NL VGNC VGNC:79707
Canis familiaris WBP2NL VGNC VGNC:48342
Bos taurus WBP2NL VGNC VGNC:36873
Mus musculus WBP2NL MGD MGI:1921966
Others WBP2NL NCBI