Jup - junction plakoglobin Gene

Also Known as PG; Ctnng; D930025P04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16480

Summary

Enables alpha-catenin binding activity. Acts upstream of or within cell-cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including Z disc; adherens junction; and intermediate filament. Part of catenin complex. Is expressed in several structures, including alimentary system; musculature; nervous system; reproductive system; and sensory organ. Used to study arrhythmogenic right ventricular dysplasia 12 and epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Apr 2022]

Jup Products (1)

mRNA Protein Name
NM_010593.2 NP_034723.1 junction plakoglobin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables alpha-catenin binding IPI
IPI: Inferred from physical interaction
14579029 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12847106 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
12847106 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8954745 MGI
acts upstream of or within desmosome assembly IMP
IMP: Inferred from mutant phenotype
8954745 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
8954745 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in Z disc IDA
IDA: Inferred from direct assay
8821035 MGI
located in adherens junction IDA
IDA: Inferred from direct assay
8582267 MGI
part of catenin complex IDA
IDA: Inferred from direct assay
8853988 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12847106 MGI
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12847106 MGI
located in desmosome IDA
IDA: Inferred from direct assay
9864371 MGI
located in desmosome IMP
IMP: Inferred from mutant phenotype
18496566 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
16917092 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junction plakoglobin

  • desmoplakin III

  • desmoplakin-3

  • gamma-catenin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS07061 JUP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18118 Jup Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24592 Jup Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jup NCBI NCBI:3728