Lfng - LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16848

Summary

Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in lymphocyte differentiation; negative regulation of Notch signaling pathway involved in somitogenesis; and somitogenesis. Acts upstream of or within several processes, including compartment pattern specification; positive regulation of Notch signaling pathway; and regulation of somitogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; inner ear; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Lfng Products (1)

mRNA	Protein	Name
NM_008494.3	NP_032520.1	beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IDA IDA: Inferred from direct assay	16221665	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	19217325	MGI
acts upstream of or within compartment pattern specification	IMP IMP: Inferred from mutant phenotype	12001066	MGI
involved in marginal zone B cell differentiation	IMP IMP: Inferred from mutant phenotype	19217325	MGI
involved in negative regulation of Notch signaling pathway involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	23072809	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	15659488	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	15574878	MGI
acts upstream of or within positive regulation of meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	15659488	MGI
acts upstream of or within positive regulation of protein binding	IDA IDA: Inferred from direct assay	15574878	MGI
involved in regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	16385447	MGI
involved in regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	28089369	MGI
acts upstream of or within regulation of somitogenesis	IMP IMP: Inferred from mutant phenotype	19779553	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	18234727	MGI
involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	23072809	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
beta-1,3-N-acetylglucosaminyltransferase lunatic fringe	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase lunatic fringe

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07601	LFNG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22217	Lfng Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28739	Lfng Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lfng	NCBI	NCBI:3955