Lrp1 - low density lipoprotein receptor-related protein 1 Gene

Also Known as Lrp; A2mr; CD91; b2b1554Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16971

Summary

Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of transport. Acts upstream of or within several processes, including apoptotic cell clearance; Cholesterol metabolic process; and heart development. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrp1 Products (1)

mRNA Protein Name
NM_008512.2 NP_032538.2 prolow-density lipoprotein receptor-related protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
3266596 MGI
enables cargo receptor activity IMP
IMP: Inferred from mutant phenotype
21289173 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10772929 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
31023188 MGI
Biological Process GO Annotation Evidence References Source
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
19098903 MGI
involved in amyloid-beta clearance by cellular catabolic process IDA
IDA: Inferred from direct assay
21289173 MGI
involved in amyloid-beta clearance by cellular catabolic process IGI
IGI: Inferred from genetic interaction
24305823 MGI
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: Inferred from mutant phenotype
23152628 MGI
involved in amyloid-beta clearance by transcytosis IDA
IDA: Inferred from direct assay
20630619 MGI
involved in aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
19742316 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
15647754 MGI
involved in astrocyte activation involved in immune response IGI
IGI: Inferred from genetic interaction
23152628 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in cellular response to amyloid-beta IGI
IGI: Inferred from genetic interaction
23152628 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
17920016 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: Inferred from mutant phenotype
31023188 MGI
involved in lysosomal transport IDA
IDA: Inferred from direct assay
26370502 MGI
involved in negative regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
31023188 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
16207730 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
31023188 MGI
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: Inferred from mutant phenotype
19742316 MGI
involved in negative regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
19742316 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
31023188 MGI
involved in positive regulation of amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
26619118 MGI
involved in positive regulation of cholesterol efflux IMP
IMP: Inferred from mutant phenotype
19718435 MGI
involved in positive regulation of lipid transport IMP
IMP: Inferred from mutant phenotype
19718435 MGI
involved in positive regulation of transcytosis IMP
IMP: Inferred from mutant phenotype
26619118 MGI
acts upstream of or within receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
21795536 MGI
involved in receptor-mediated endocytosis IGI
IGI: Inferred from genetic interaction
21289173 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
21289173 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
19742316 MGI
involved in regulation of cholesterol transport IMP
IMP: Inferred from mutant phenotype
19718435 MGI
involved in regulation of phospholipase A2 activity IMP
IMP: Inferred from mutant phenotype
19718435 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: Inferred from Experiment
23760271 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
23760271 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
23760271 MGI
involved in regulation of pulmonary blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
31023188 MGI
involved in transport across blood-brain barrier IMP
IMP: Inferred from mutant phenotype
20630619 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19299737 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23760271 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23760271 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
23760271 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23760271 MGI
located in membrane IDA
IDA: Inferred from direct assay
15082773 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
3266596 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
23760271 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
23760271 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolow-density lipoprotein receptor-related protein 1

  • LRP-1

  • alpha 2-macroglobulin receptor

  • lipoprotein receptor-related protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P4073 ANG1005 98.83% Phase 3

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100447 TM5275 sodium Inhibitor 98.97% Unkown
HY-P10502A L57 acetate 99.01% Unkown
HY-P10502 L57 99.44% Unkown
HY-172699A DSPE-PEG3400-ANG 95.0% Unkown
HY-165426 HB-230 91.2% Unkown
HY-N9454 Garcinoic acid / Unkown
HY-RS23105 Lrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183626 PAI-1-IN-1 99.45% Unkown
HY-172698 DSPE-PEG1000-ANG / Unkown
HY-172699 DSPE-PEG2000-ANG / Unkown
HY-172700 DSPE-PEG5000-ANG / Unkown
HY-179459 SJ-300 Inhibitor / Unkown
HY-P10911 IETP2 Ligand / Unkown
HY-RS01706 C1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07792 LRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07796 LRP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183877 YO-2 / Unkown
HY-RS16670 Lrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22618 Lrp1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS29133 Lrp1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990202 Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) Inhibitor 98.10% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp1 NCBI NCBI:4035