Slc8b1 - solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Gene

Also Known as NCLX; NCKX6; Slc24a6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170756

Summary

Enables calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential and protein homodimerization activity. Involved in calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and regulation of lymphocyte chemotaxis. Acts upstream of or within mitochondrial calcium ion transmembrane transport and sodium ion transmembrane transport. Located in mitochondrion and plasma membrane. Is expressed in forelimb bud. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Apr 2022]

Slc8b1 Products (3)

mRNA Protein Name
NM_001177594.1 NP_001171065.1 mitochondrial sodium/calcium exchanger protein isoform 2 precursor
NM_001177595.1 NP_001171066.1 mitochondrial sodium/calcium exchanger protein isoform 3 precursor
NM_133221.2 NP_573484.2 mitochondrial sodium/calcium exchanger protein isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium:sodium antiporter activity IDA
IDA: Inferred from direct assay
14625281 MGI
enables calcium:sodium antiporter activity IMP
IMP: Inferred from mutant phenotype
28445457 MGI
enables calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential IMP
IMP: Inferred from mutant phenotype
24067497 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20018762 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium export from the mitochondrion IMP
IMP: Inferred from mutant phenotype
24067497 MGI
acts upstream of or within calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
14625281 MGI
involved in mitochondrial calcium ion homeostasis IDA
IDA: Inferred from direct assay
20018762 MGI
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
28445457 MGI
acts upstream of or within mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
20018762 MGI
involved in mitochondrial calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
28445457 MGI
involved in regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
20018762 MGI
involved in regulation of lymphocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
27328625 MGI
acts upstream of or within sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
14625281 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
20018762 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14625281 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial sodium/calcium exchanger protein

  • Na(+)/K(+)/Ca(2+)-exchange protein 6

  • sodium/calcium exchanger protein, mitochondrial

  • sodium/potassium/calcium exchanger 6, mitochondrial

  • solute carrier family 24 (sodium/potassium/calcium exchanger), member 6

  • solute carrier family 24 member 6

  • solute

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13340 SLC8B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20598 Slc8b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27106 Slc8b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc8b1 NCBI NCBI:80024