Klc1 - kinesin light chain 1 Gene

Also Known as Kns2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171041

Summary

Enables tubulin binding activity. Involved in intracellular protein transport and protein localization to synapse. Located in several cellular components, including growth cone; neuronal cell body; and vesicle. Part of Kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Orthologous to human KLC1 (Kinesin light chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Klc1 Products (3)

mRNA Protein Name
NM_001081972.1 NP_001075441.1 kinesin light chain 1 isoform A
NM_001081973.1 NP_001075442.1 kinesin light chain 1 isoform B
NM_001081974.1 NP_001075443.1 kinesin light chain 1 isoform C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14963148 RGD
enables tubulin binding IDA
IDA: Inferred from direct assay
15935053 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular protein transport IMP
IMP: Inferred from mutant phenotype
19861499 RGD
involved in protein localization to synapse IMP
IMP: Inferred from mutant phenotype
19861499 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15935053 RGD
located in growth cone IDA
IDA: Inferred from direct assay
14970196 RGD
part of kinesin complex IDA
IDA: Inferred from direct assay
1946431 RGD
located in membrane IDA
IDA: Inferred from direct assay
14985359 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15935053 RGD
located in vesicle IDA
IDA: Inferred from direct assay
14970196 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin light chain 1

  • KLC 1

  • kinesin 2

Klc1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Klc1 P37285 OPG164 vaccinia virus P68619
Pull Down
14963148
Cross
Klc1 P37285 OPG164 vaccinia virus P68619
Protein 3 Hybrid
14963148
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07326 KLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18619 Klc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25105 Klc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klc1 NCBI NCBI:3831