2. Gene
  3. KLC1 - kinesin light chain 1 Gene

KLC1 - kinesin light chain 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KLC; KNS2; KNS2A

Gene ID: 3831 | Gene type: protein coding

About KLC1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,629,211-103,701,544 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues and 5 paralogues. Broad expression in brain (RPKM 108.4), heart (RPKM 21.0) and 23 other tissues.

Summary

Conventional Kinesin is a tetrameric molecule composed of two heavy chains and two LIGHT chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the LIGHT chains bind to various cargos. This gene encodes a member of the Kinesin light chain family. It associates with Kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, Kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / Kinesin heavy chain subfamily of Kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

KLC1 Products(32)

mRNA Protein Name
NM_001130107.2 NP_001123579.1 kinesin light chain 1 isoform 3
NM_001394832.1 NP_001381761.1 kinesin light chain 1 isoform 4
NM_001394833.1 NP_001381762.1 kinesin light chain 1 isoform 5
NM_001394834.1 NP_001381763.1 kinesin light chain 1 isoform 6
NM_001394835.1 NP_001381764.1 kinesin light chain 1 isoform 7
NM_001394836.1 NP_001381765.1 kinesin light chain 1 isoform 8
NM_001394837.1 NP_001381766.1 kinesin light chain 1 isoform 9
NM_001394838.1 NP_001381767.1 kinesin light chain 1 isoform 10
NM_001394839.1 NP_001381768.1 kinesin light chain 1 isoform 11
NM_001394840.1 NP_001381769.1 kinesin light chain 1 isoform 12
NM_001394841.1 NP_001381770.1 kinesin light chain 1 isoform 13
NM_001394842.1 NP_001381771.1 kinesin light chain 1 isoform 14
NM_001394843.1 NP_001381772.1 kinesin light chain 1 isoform 15
NM_001394844.1 NP_001381773.1 kinesin light chain 1 isoform 16
NM_001394845.1 NP_001381774.1 kinesin light chain 1 isoform 17
NM_001394846.1 NP_001381775.1 kinesin light chain 1 isoform 18
NM_001394847.1 NP_001381776.1 kinesin light chain 1 isoform 19
NM_001394848.1 NP_001381777.1 kinesin light chain 1 isoform 20
NM_001394849.1 NP_001381778.1 kinesin light chain 1 isoform 21
NM_001394850.1 NP_001381779.1 kinesin light chain 1 isoform 22
NM_001394851.1 NP_001381780.1 kinesin light chain 1 isoform 23
NM_001394852.1 NP_001381781.1 kinesin light chain 1 isoform 24
NM_001394853.1 NP_001381782.1 kinesin light chain 1 isoform 25
NM_001394854.1 NP_001381783.1 kinesin light chain 1 isoform 26
NM_001394855.1 NP_001381784.1 kinesin light chain 1 isoform 27
NM_001394856.1 NP_001381785.1 kinesin light chain 1 isoform 28
NM_001394857.1 NP_001381786.1 kinesin light chain 1 isoform 29
NM_001394858.1 NP_001381787.1 kinesin light chain 1 isoform 30
NM_001394859.1 NP_001381788.1 kinesin light chain 1 isoform 31
NM_001394860.1 NP_001381789.1 kinesin light chain 1 isoform 32
NM_005552.5 NP_005543.2 kinesin light chain 1 isoform 1
NM_182923.4 NP_891553.2 kinesin light chain 1 isoform 2

KLC1 Protein Structure

Rab5-bind

Rab5-bind: Rabaptin-like protein (80 - 254)

TPR_2

TPR_2: Tetratricopeptide repeat (258 - 285)

TPR_12

TPR_12: Tetratricopeptide repeat (293 - 370)

TPR_1

TPR_1: Tetratricopeptide repeat (381 - 410)

TPR_10

TPR_10: Tetratricopeptide repeat (465 - 495)

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  • 573 a.a.
Protein Preferred Names Protein Names

kinesin light chain 1

kinesin 2 60/70kDa

Related Diseases

Diseases Alias
Melanoma, Cutaneous Malignant 6

Melanoma, Cutaneous Malignant, Susceptibility To, 6

CMM6

Melanoma, Cutaneous Malignant, 6

Cutaneous Malignant Melanoma 6

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 6
Lung Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Neuroendocrine Carcinoma Of Lung

Pulmonary Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Lung Neuroendocrine Carcinoma
Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe

Malignant Neoplasm Of Occipital Lobe

Tumor Of Occipital Lobe
Cataract 28

CTRCT28

Cataract, Age-Related Cortical, 1

Arcc1

Cataract 28, Age-Related Cortical, Susceptibility To

Cataract 28, Age-Related Cortical

Age-Related Cortical Cataract 1
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07326 KLC1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KLC1 MGD MGI:107978
Felis catus KLC1 VGNC VGNC:104480
Rattus norvegicus KLC1 RGD RGD:621411
Others KLC1 NCBI