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Gper1 - G protein-coupled estrogen receptor 1 Gene

Also Known as Gper; GPR41; Gpr30

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171104

Summary

Enables estradiol binding activity and Estrogen receptor activity. Involved in several processes, including apoptotic nuclear changes; cellular response to organic cyclic compound; and positive regulation of signal transduction. Acts upstream of with a positive effect on vasodilation. Located in several cellular components, including dendrite; postsynaptic density; and presynaptic membrane. Orthologous to human GPER1 (G protein-coupled Estrogen receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gper1 Products (1)

mRNA	Protein	Name
NM_133573.2	NP_598257.2	G-protein coupled estrogen receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled estrogen receptor activity	IDA IDA: Inferred from direct assay	23283935	RGD
enables estradiol binding	IMP IMP: Inferred from mutant phenotype	24262995	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic chromosome condensation	IDA IDA: Inferred from direct assay	23907461	RGD
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	23283935	RGD
involved in cellular response to mineralocorticoid stimulus	IDA IDA: Inferred from direct assay	23283935	RGD
involved in estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20445128	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	23907461	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	23907461	RGD
involved in nuclear fragmentation involved in apoptotic nuclear change	IDA IDA: Inferred from direct assay	23907461	RGD
involved in nuclear receptor-mediated steroid hormone signaling pathway	IDA IDA: Inferred from direct assay	20445128	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19717735	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19717735	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	23907461	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22975889	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	23907461	RGD
involved in positive regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	23283935	RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20445128	RGD
involved in positive regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	23907461	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23907461	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23641788	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	19717735	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19717735	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	24262995	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20445128	RGD
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	23907461	RGD
involved in positive regulation of voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	24097558	RGD
involved in serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19095043	RGD
acts upstream of positive effect vasodilation	IDA IDA: Inferred from direct assay	23283935	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	30354811	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	22919059	RGD
located in axon	IDA IDA: Inferred from direct assay	22919059	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	22919059	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	22919059	RGD
located in dendrite	IDA IDA: Inferred from direct assay	22919059	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	22919059	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	22919059	RGD
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	22919059	RGD
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	24262995	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	22919059	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19095043	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	22919059	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	22919059	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	23822769	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	23822769	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
G-protein coupled estrogen receptor 1	G-protein coupled receptor 30 G-protein coupled receptor 41 chemoattractant receptor-like 2 chemokine receptor-like 2 mER membrane estrogen receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05636	GPER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18518	Gper1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25000	Gper1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gper1	NCBI	NCBI:2852