GPER1 - G protein-coupled estrogen receptor 1 Gene

Also Known as mER; CEPR; GPER; DRY12; FEG-1; GPR30; LERGU; LyGPR; CMKRL2; LERGU2; GPCR-Br

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2852

About GPER1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,087,118-1,093,810 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in fat (RPKM 4.9), kidney (RPKM 3.0) and 22 other tissues.

Summary

This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of Adenylate Cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]

GPER1 Products (3)

mRNA	Protein	Name
NM_001039966.2	NP_001035055.1	G-protein coupled estrogen receptor 1
NM_001098201.3	NP_001091671.1	G-protein coupled estrogen receptor 1
NM_001505.3	NP_001496.1	G-protein coupled estrogen receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	20551055	GOA
enables nuclear estrogen receptor activity	IDA IDA: Inferred from direct assay	15539556	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20551055	GOA
enables steroid binding	IDA IDA: Inferred from direct assay	15539556	GOA
enables steroid hormone binding	IDA IDA: Inferred from direct assay	19931550	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15539556	GOA
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15539556	GOA
involved in cellular response to peptide hormone stimulus	IDA IDA: Inferred from direct assay	21427217	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	23285008	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of cell cycle process	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	23285008	GOA
involved in negative regulation of leukocyte activation	IDA IDA: Inferred from direct assay	23285008	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in nuclear receptor-mediated steroid hormone signaling pathway	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20551055	GOA
involved in positive regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15539556	GOA
involved in positive regulation of cardiac vascular smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20551055	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20551055	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23840305	GOA
involved in positive regulation of inositol trisphosphate biosynthetic process	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	23674134	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20551055	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	15705806	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20551055	GOA
involved in positive regulation of uterine smooth muscle contraction	IDA IDA: Inferred from direct assay	21427217	GOA
involved in steroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	19931550	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15705806	GOA
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	21540189	GOA
located in early endosome	IDA IDA: Inferred from direct assay	21540189	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15705806	GOA
located in keratin filament	IDA IDA: Inferred from direct assay	21149639	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	15705806	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20551055	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21540189	GOA
NOT located in plasma membrane	IDA IDA: Inferred from direct assay	15705806	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15539556	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	21540189	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	21540189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPER1 Protein Structure

7tm_1

0
100
200
300
375 a.a.

Protein Preferred Names	Protein Names
G-protein coupled estrogen receptor 1	G protein-coupled receptor 30

GPER1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81150	GPR30 Antibody	WB, IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P86196	GPR30 Antibody (YA5888)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Teeth Hard Tissue Disease
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Adenomyosis	Endometriosis Of Uterus Endometriosis Interna Endometriosis Of Myometrium Endometriosis, Myometrium Uterine Adenomyosis Adenomyosis Uteri Internal Endometriosis
Gynecomastia
Seminoma	Seminoma, Pure
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Estrogen-Receptor Negative Breast Cancer
Estrogen Excess	Hyperestrogenism
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Aromatase Excess Syndrome	AEXS Increased Aromatase Activity Familial Hyperestrogenism Hereditary Prepubertal Gynecomastia Aromatase Activity, Increased Familial Gynecomastia Due To Increased Aromatase Activity Hereditary Gynecomastia Gynecomastia, Familial Familial Gynecomastia
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Scoliosis
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05636	GPER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18518	Gper1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25000	Gper1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPER1	VGNC	VGNC:73132
Rattus norvegicus	GPER1	RGD	RGD:619845
Canis familiaris	GPER1	VGNC	VGNC:41379
Mus musculus	GPER1	MGD	MGI:1924104
Felis catus	GPER1	VGNC	VGNC:107757
Bos taurus	GPER1	VGNC	VGNC:29532
Others	GPER1	NCBI