Pde5a - phosphodiesterase 5A Gene

Rattus norvegicus

Also known as PDE5A2

Gene ID: 171115 | Gene type: protein coding

About Pde5a

Primary_assembly 2: 210,858,063-210,999,701 forward strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 17 phenotypes. Biased expression in Lung (RPKM 466.), Brain (RPKM 88.6) and 6 other tissues.

Summary

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including blood vessel diameter maintenance; response to testosterone; and short-term memory. Located in cytosol. Used to study artery disease (multiple); impotence (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Pde5a Products(1)

mRNA	Protein	Name
NM_133584.1	NP_598268.1	cGMP-specific 3',5'-cyclic phosphodiesterase

Pde5a Protein Structure

GAF

PDEase_I

0
200
400
600
800
865 a.a.

Protein Preferred Names

Protein Names

cGMP-specific 3',5'-cyclic phosphodiesterase

CGB-PDE	cGMP-binding cGMP specific phosphodiesterase 5A2
cGMP-binding cGMP-specific phosphodiesterase	phosphodiesterase 5A, cGMP-specific
phosphodiesterase type 5

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112831	Osoresnontrine	Inhibitor	99.88%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1343	Robustine	Inhibitor	99.97%	Unkown
HY-RS10227	PDE5A Human Pre-designed siRNA Set A		/	Unkown
HY-RS10228	Pde5a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10229	Pde5a Rat Pre-designed siRNA Set A		/	Unkown
HY-106230A	Dasantafil	Inhibitor	98.35%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pde5a	NCBI	NCBI:8654
Mus musculus	Pde5a	NCBI	NCBI:242202

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