Pde5a - phosphodiesterase 5A Gene

Also Known as PDE5A2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171115

About Pde5a

Primary_assembly 2: 210,858,063-210,999,701 forward strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 17 phenotypes. Biased expression in Lung (RPKM 466.), Brain (RPKM 88.6) and 6 other tissues.

Summary

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including blood vessel diameter maintenance; response to testosterone; and short-term memory. Located in cytosol. Used to study artery disease (multiple); impotence (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Pde5a Products (1)

mRNA Protein Name
NM_133584.1 NP_598268.1 cGMP-specific 3',5'-cyclic phosphodiesterase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
15100365 RGD
Biological Process GO Annotation Evidence References Source
involved in nervous system development IEP
IEP: Inferred from expression pattern
9370351 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19474186 RGD
involved in positive regulation of chronic inflammatory response IMP
IMP: Inferred from mutant phenotype
19129291 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
19542492 RGD
involved in regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
17606845 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
12466227 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17141339 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
17138653 RGD
involved in short-term memory IMP
IMP: Inferred from mutant phenotype
19129291 RGD
involved in vasodilation IEP
IEP: Inferred from expression pattern
16545481 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde5a Protein Structure

GAF

GAF: smart00065 (153 - 310)

GAF

GAF: smart00065 (336 - 502)

PDEase_I

PDEase_I: pfam00233 (601 - 835)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 865 a.a.
Protein Preferred Names Protein Names

cGMP-specific 3',5'-cyclic phosphodiesterase

  • CGB-PDE

  • cGMP-binding cGMP specific phosphodiesterase 5A2

  • cGMP-binding cGMP-specific phosphodiesterase

  • phosphodiesterase 5A, cGMP-specific

  • phosphodiesterase type 5

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-106230A Dasantafil Inhibitor 98.35% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-170435 PDE5-IN-13 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1343 Robustine Inhibitor 99.70% Unkown
HY-103084 PDE5-IN-1 Inhibitor / Unkown
HY-161851 MDL3 Inhibitor / Unkown
HY-N17363 Confusameline / Unkown
HY-RS10227 PDE5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10228 Pde5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10229 Pde5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde5a NCBI NCBI:8654