Mark3 - MAP/microtubule affinity regulating kinase 3 Gene

Also Known as ETK1; Emk2; ETK-1; MPK10; C-TAK1; 1600015G02Rik; A430080F22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17169

Summary

Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; peptidyl-serine autophosphorylation; and positive regulation of protein binding activity. Predicted to act upstream of or within phosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mark3 Products (4)

mRNA Protein Name
NM_001370744.1 NP_001357673.1 MAP/microtubule affinity-regulating kinase 3 isoform 3
NM_001370745.1 NP_001357674.1 MAP/microtubule affinity-regulating kinase 3 isoform 4
NM_021516.4 NP_067491.2 MAP/microtubule affinity-regulating kinase 3 isoform 1
NM_022801.4 NP_073712.2 MAP/microtubule affinity-regulating kinase 3 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28087714 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAP/microtubule affinity-regulating kinase 3

  • ELKL motif kinase 2

  • EMK-2

  • EMK2/MARK3 serine-threonine protein kinase

  • MPK-10

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182743 OICR19451 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mark3 NCBI NCBI:4140