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MARK3 - microtubule affinity regulating kinase 3 Gene

Also Known as KP78; VIPB; CTAK1; PAR1A; Par-1a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4140

About MARK3

Cytogenetic location: 14q32.32-q32.33 Genomic coordinates (GRCh38): 14:103,385,415-103,503,831 (from NCBI)

This gene has 81 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 22.5), testis (RPKM 17.6) and 25 other tissues.

Summary

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

MARK3 Products (7)

mRNA	Protein	Name
NM_001128918.3	NP_001122390.2	MAP/microtubule affinity-regulating kinase 3 isoform a
NM_001128919.3	NP_001122391.2	MAP/microtubule affinity-regulating kinase 3 isoform b
NM_001128920.3	NP_001122392.2	MAP/microtubule affinity-regulating kinase 3 isoform d
NM_001128921.3	NP_001122393.2	MAP/microtubule affinity-regulating kinase 3 isoform e
NM_001411055.1	NP_001397984.1	MAP/microtubule affinity-regulating kinase 3 isoform f
NM_001411056.1	NP_001397985.1	MAP/microtubule affinity-regulating kinase 3 isoform g
NM_002376.7	NP_002367.5	MAP/microtubule affinity-regulating kinase 3 isoform c

MARK3 Protein Structure

Pkinase

KA1

0
200
400
600
753 a.a.

Protein Preferred Names	Protein Names
MAP/microtubule affinity-regulating kinase 3	C-TAK1

MARK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MARK3	P27448	RIMS1	Homo sapiens	Q86UR5	Anti Bait CoIP	37207277
Intra	MARK3	P27448	HCN1	Homo sapiens	O60741	Anti Bait CoIP	37207277
Cross	MARK3	P27448	ORF9b	Human SARS coronavirus	Q6S8E0	Y2H Pooling	22046132
Cross	MARK3	P27448	ORF9b	Human SARS coronavirus	Q6S8E0	Lumier	22046132
Intra	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
Intra	MARK3	P27448	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Far-WB	15161933
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	25852190
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	TAP	16306228
Intra	MARK3	P27448	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAE	Homo sapiens	P62258	TAP	16306228
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	Pull Down	32707033
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	CoIP	15324660
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	16959763
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
Intra	MARK3	P27448	YWHAG	Homo sapiens	P61981	Pull Down	32707033
Intra	MARK3	P27448	SFN	Homo sapiens	P31947	TAP	15778465
Intra	MARK3	P27448	ASB13	Homo sapiens	Q8WXK3	Y2H Pooling	16169070
Cross	MARK3	P27448	Ppm1l	Mus musculus	Q8BHN0	Phosphatase Assay	12556533
Cross	MARK3	P27448	Ppm1l	Mus musculus	Q8BHN0	Anti Bait CoIP	12556533

Cross: Cross-species interaction Intra: Intraspecies interaction

MARK3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82405	MARK3 Antibody (YA2150)	WB, ICC/IF, IP, FC	Mouse, Human
HY-P84225	MARK3 Antibody (YA3922)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat,
HY-P84225A	MARK3 Antibody (YA3922)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat,

Related Diseases

Diseases	Alias
Visual Impairment And Progressive Phthisis Bulbi	VIPB Eye Diseases
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Acute Cystitis	Urinary Tract Infection Recurrent Urinary Tract Infection
Gaucher Disease, Type Iii	Gaucher Disease, Subacute Neuronopathic Type Gd Iii Gaucher Disease, Chronic Neuronopathic Type Gaucher Disease, Juvenile And Adult, Cerebral Gaucher Disease Type 3 GD3 Gaucher'S Disease Type Iii Gaucher Disease Type Iii Gd 3 Cerebral Juvenile And Adult Form Of Gaucher Disease Chronic Neuronopathic Gaucher Disease Gaucher Disease 3 Cerebral, Juvenile And Adult, Gaucher Disease Gaucher Disease Chronic Neuronopathic Type Gaucher Disease Type Ii Subacute Neuronopathic Gaucher Disease Type 3 Gaucher Disease Gaucher Disease, Type 3 Gaucher Disease, Type 2
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-182743	OICR19451	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MARK3	MGD	MGI:1341865
Canis familiaris	MARK3	VGNC	VGNC:43025
Macaca mulatta	MARK3	VGNC	VGNC:74659
Bos taurus	MARK3	VGNC	VGNC:31249
Felis catus	MARK3	VGNC	VGNC:68185
Rattus norvegicus	MARK3	RGD	RGD:619883
Others	MARK3	NCBI