Mbd4 - methyl-CpG binding domain protein 4 Gene

Also Known as Med1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17193

Summary

Enables DNA binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2 DNA damage checkpoint signaling; and response to radiation. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including central nervous system; lower urogenital tract; reproductive system; retina; and urethra epithelium. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus squamous cell carcinoma; lung cancer; and rheumatoid arthritis. Orthologous to human MBD4 (methyl-CpG binding domain 4, DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]

Mbd4 Products (6)

mRNA Protein Name
NM_001410106.1 NP_001397035.1 methyl-CpG-binding domain protein 4 isoform 2
NM_001410107.1 NP_001397036.1 methyl-CpG-binding domain protein 4 isoform 3
NM_001410108.1 NP_001397037.1 methyl-CpG-binding domain protein 4 isoform 4
NM_001410109.1 NP_001397038.1 methyl-CpG-binding domain protein 4 isoform 5
NM_001410110.1 NP_001397039.1 methyl-CpG-binding domain protein 4 isoform 6
NM_010774.3 NP_034904.2 methyl-CpG-binding domain protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9774669 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
14562041 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
14562041 MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
14614141 MGI
acts upstream of or within response to radiation IMP
IMP: Inferred from mutant phenotype
14562041 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
9774669 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17546630 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9774669 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methyl-CpG-binding domain protein 4

  • methyl-CpG-binding protein MBD4

  • mismatch-specific DNA N-glycosylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08184 MBD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19616 Mbd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26111 Mbd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mbd4 NCBI NCBI:8930