Mef2d - myocyte enhancer factor 2D Gene
Species: Mus musculus
Gene Type: protein coding
Gene ID: 17261
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein dimerization activity. Acts upstream of or within several processes, including osteoblast differentiation; skeletal muscle cell differentiation; and skeletal system development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; dorsal aorta; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human MEF2D (myocyte enhancer factor 2D). [provided by Alliance of Genome Resources, Apr 2022]
Mef2d Products (32)
| mRNA | Protein | Name |
|---|---|---|
| NM_001310587.2 | NP_001297516.1 | myocyte-specific enhancer factor 2D isoform 1 |
| NM_001310593.2 | NP_001297522.1 | myocyte-specific enhancer factor 2D isoform 3 |
| NM_001410077.1 | NP_001397006.1 | myocyte-specific enhancer factor 2D isoform 1 |
| NM_001410078.1 | NP_001397007.1 | myocyte-specific enhancer factor 2D isoform 1 |
| NM_001410079.1 | NP_001397008.1 | myocyte-specific enhancer factor 2D isoform 4 |
| NM_001410080.1 | NP_001397009.1 | myocyte-specific enhancer factor 2D isoform 4 |
| NM_001410081.1 | NP_001397010.1 | myocyte-specific enhancer factor 2D isoform 4 |
| NM_001410082.1 | NP_001397011.1 | myocyte-specific enhancer factor 2D isoform 4 |
| NM_001410083.1 | NP_001397012.1 | myocyte-specific enhancer factor 2D isoform 4 |
| NM_001410084.1 | NP_001397013.1 | myocyte-specific enhancer factor 2D isoform 5 |
| NM_001410085.1 | NP_001397014.1 | myocyte-specific enhancer factor 2D isoform 2 |
| NM_001410086.1 | NP_001397015.1 | myocyte-specific enhancer factor 2D isoform 3 |
| NM_001410087.1 | NP_001397016.1 | myocyte-specific enhancer factor 2D isoform 3 |
| NM_001410088.1 | NP_001397017.1 | myocyte-specific enhancer factor 2D isoform 6 |
| NM_001410089.1 | NP_001397018.1 | myocyte-specific enhancer factor 2D isoform 7 |
| NM_001410090.1 | NP_001397019.1 | myocyte-specific enhancer factor 2D isoform 8 |
| NM_001410091.1 | NP_001397020.1 | myocyte-specific enhancer factor 2D isoform 9 |
| NM_001410092.1 | NP_001397021.1 | myocyte-specific enhancer factor 2D isoform 9 |
| NM_001410093.1 | NP_001397022.1 | myocyte-specific enhancer factor 2D isoform 10 |
| NM_001410094.1 | NP_001397023.1 | myocyte-specific enhancer factor 2D isoform 11 |
| NM_001410095.1 | NP_001397024.1 | myocyte-specific enhancer factor 2D isoform 12 |
| NM_001410096.1 | NP_001397025.1 | myocyte-specific enhancer factor 2D isoform 12 |
| NM_001410097.1 | NP_001397026.1 | myocyte-specific enhancer factor 2D isoform 12 |
| NM_001410098.1 | NP_001397027.1 | myocyte-specific enhancer factor 2D isoform 13 |
| NM_001410099.1 | NP_001397028.1 | myocyte-specific enhancer factor 2D isoform 13 |
| NM_001410100.1 | NP_001397029.1 | myocyte-specific enhancer factor 2D isoform 13 |
| NM_001410101.1 | NP_001397030.1 | myocyte-specific enhancer factor 2D isoform 14 |
| NM_001410102.1 | NP_001397031.1 | myocyte-specific enhancer factor 2D isoform 14 |
| NM_001410103.1 | NP_001397032.1 | myocyte-specific enhancer factor 2D isoform 15 |
| NM_001410104.1 | NP_001397033.1 | myocyte-specific enhancer factor 2D isoform 15 |
| NM_001410105.1 | NP_001397034.1 | myocyte-specific enhancer factor 2D isoform 16 |
| NM_133665.5 | NP_598426.1 | myocyte-specific enhancer factor 2D isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables DNA binding |
IDA
IDA: Inferred from direct assay
|
15491989 | MGI |
| enables DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA
IDA: Inferred from direct assay
|
7760790 | MGI |
| enables DNA-binding transcription factor activity |
IDA
IDA: Inferred from direct assay
|
12130539 | MGI |
| enables RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
7760790 | MGI |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
20833138 | MGI |
| enables histone deacetylase binding |
IDA
IDA: Inferred from direct assay
|
17158926 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25331958 | MGI |
| enables protein heterodimerization activity |
IPI
IPI: Inferred from physical interaction
|
9858528 | MGI |
| enables protein homodimerization activity |
IPI
IPI: Inferred from physical interaction
|
9858528 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
17158926 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
15024082 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myocyte-specific enhancer factor 2D |
|
Related Agents
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Pre-clinical Phase
Bioactive Molecules
(5)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-128341 | ERK5-IN-2 | Inhibitor | 98.45% | Unkown |
| HY-139254 | Indirubin-3′-oxime | 99.10% | Unkown | |
| HY-RS08312 | MEF2D Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS17303 | Mef2d Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS23758 | Mef2d Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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