Mme - membrane metallo endopeptidase Gene

Also Known as NEP; SFE; CD10; CALLA; 6030454K05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17380

Summary

Enables peptidase activity. Involved in amyloid-beta clearance; positive regulation of long-term synaptic potentiation; and sensory perception of pain. Acts upstream of or within amyloid-beta metabolic process. Located in several cellular components, including dendrite; neuron projection terminus; and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and mammary gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Mme Products (4)

mRNA Protein Name
NM_001289462.1 NP_001276391.1 neprilysin
NM_001289463.1 NP_001276392.1 neprilysin
NM_001357335.1 NP_001344264.1 neprilysin
NM_008604.4 NP_032630.2 neprilysin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
15944124 MGI
Biological Process GO Annotation Evidence References Source
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
16636059 MGI
acts upstream of or within amyloid-beta metabolic process IDA
IDA: Inferred from direct assay
12074840 MGI
involved in positive regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
16636059 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
9751784 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
12074840 MGI
located in dendrite IDA
IDA: Inferred from direct assay
12074840 MGI
located in membrane IDA
IDA: Inferred from direct assay
15944124 MGI
located in neuron projection terminus IDA
IDA: Inferred from direct assay
12074840 MGI
located in synapse IDA
IDA: Inferred from direct assay
12074840 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
12074840 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neprilysin

  • atriopeptidase

  • common acute lymphoblastic leukemia antigen

  • enkephalinase

  • neutral endopeptidase 24.11

  • skin fibroblast elastase

Recombinant Mme Proteins

Cat. No. Product Name Accession Purity
HY-P72878 MME Protein, Mouse (HEK293, His) Q61391/NP_032630.2 (Y52-W750) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-165037 1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol / Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08513 MME Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08522 MMP12 Human Pre-designed siRNA Set A / Unkown
HY-RS08523 Mmp12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08524 Mmp12 Rat Pre-designed siRNA Set A / Unkown
HY-RS17321 Mme Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23776 Mme Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mme NCBI NCBI:4311