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Cited2 - Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 Gene

Also Known as Mrg1; Msg2; p35srj; ER154-like

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17684

Summary

Enables several functions, including SMAD binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; left/right axis specification; and positive regulation of male gonad development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryo development. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Used to study tetralogy of Fallot. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2). [provided by Alliance of Genome Resources, Apr 2022]

Cited2 Products (1)

mRNA	Protein	Name
NM_010828.3	NP_034958.2	cbp/p300-interacting transactivator 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11694877	MGI
enables SMAD binding	IPI IPI: Inferred from physical interaction	16619037	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15475956	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10593900	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10593900	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adrenal cortex formation	IMP IMP: Inferred from mutant phenotype	17537799	MGI
acts upstream of or within adrenal gland development	IMP IMP: Inferred from mutant phenotype	11694877	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	15615595	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	20549734	MGI
NOT involved in branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17615577	MGI
acts upstream of or within cardiac neural crest cell development involved in heart development	IMP IMP: Inferred from mutant phenotype	11694877	MGI
acts upstream of or within cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	11694877	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	11823447	MGI
acts upstream of or within cranial nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	11694877	MGI
acts upstream of or within decidualization	IMP IMP: Inferred from mutant phenotype	16579983	MGI
acts upstream of or within determination of heart left/right asymmetry	IMP IMP: Inferred from mutant phenotype	15750185	MGI
involved in determination of left/right asymmetry in lateral mesoderm	IMP IMP: Inferred from mutant phenotype	15475956	MGI
involved in determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15750185	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IGI IGI: Inferred from genetic interaction	18653562	MGI
involved in embryonic heart tube left/right pattern formation	IMP IMP: Inferred from mutant phenotype	15475956	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	16579983	MGI
acts upstream of or within embryonic process involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	16579983	MGI
acts upstream of or within endocardial cushion development	IMP IMP: Inferred from mutant phenotype	15750185	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	17644732	MGI
acts upstream of or within granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	17644732	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	15750185	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	15750185	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	17644732	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16579983	MGI
NOT involved in kidney development	IMP IMP: Inferred from mutant phenotype	17615577	MGI
involved in left/right axis specification	IMP IMP: Inferred from mutant phenotype	15475956	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	18653562	MGI
acts upstream of or within leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	17644732	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	17644732	MGI
involved in liver development	IMP IMP: Inferred from mutant phenotype	17932483	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	19457926	MGI
NOT involved in morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	17615577	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17932483	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	12149478	MGI
acts upstream of or within neural tube formation	IMP IMP: Inferred from mutant phenotype	11694877	MGI
involved in nodal signaling pathway	IMP IMP: Inferred from mutant phenotype	15475956	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	11694877	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15475956	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	11694877	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9811838	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	9811838	MGI
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	17932483	MGI
involved in positive regulation of male gonad development	IMP IMP: Inferred from mutant phenotype	19457926	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17932483	MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16619037	MGI
acts upstream of or within pulmonary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	12149478	MGI
involved in regulation of animal organ formation	IMP IMP: Inferred from mutant phenotype	17537799	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15475956	MGI
involved in sex determination	IMP IMP: Inferred from mutant phenotype	19457926	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
involved in spleen development	IMP IMP: Inferred from mutant phenotype	15475956	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	20549734	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	20549734	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16619037	MGI
acts upstream of or within trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	16579983	MGI
acts upstream of or within uterus development	IMP IMP: Inferred from mutant phenotype	25976672	MGI
acts upstream of or within vasculature development	IGI IGI: Inferred from genetic interaction	18653562	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	18653562	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	16579983	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	12149478	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	15475956	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	17932483	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9811838	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cbp/p300-interacting transactivator 2	MSG-related protein 1 melanocyte specific gene 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02729	CITED2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21106	Cited2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27625	Cited2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cited2	NCBI	NCBI:10370