Mtf2 - metal response element binding transcription factor 2 Gene

Also Known as M96; Pcl2; 9230112N11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17765

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Involved in several processes, including regulation of histone H3-K27 methylation; regulation of transcription by RNA polymerase II; and segment specification. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Mtf2 Products (7)

mRNA Protein Name
NM_001253877.1 NP_001240806.1 metal-response element-binding transcription factor 2 isoform 2
NM_001253878.1 NP_001240807.1 metal-response element-binding transcription factor 2 isoform 2
NM_001253879.1 NP_001240808.1 metal-response element-binding transcription factor 2 isoform 2
NM_001253880.1 NP_001240809.1 metal-response element-binding transcription factor 2 isoform 2
NM_001359088.1 NP_001346017.1 metal-response element-binding transcription factor 2 isoform 3
NM_001359089.1 NP_001346018.1 metal-response element-binding transcription factor 2 isoform 2
NM_013827.3 NP_038855.2 metal-response element-binding transcription factor 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7772254 MGI
enables methylated histone binding IDA
IDA: Inferred from direct assay
23104054 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20064376 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in epigenetic regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20144788 MGI
involved in segment specification IMP
IMP: Inferred from mutant phenotype
21059868 MGI
involved in stem cell differentiation IMP
IMP: Inferred from mutant phenotype
20144788 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20144788 MGI
Cellular Component GO Annotation Evidence References Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
20144788 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metal-response element-binding transcription factor 2

  • mPCl2

  • metal regulatory transcription factor 2

  • metal response element DNA-binding protein M96

  • polycomb-like protein 2

  • ziRF1

  • zinc-regulated factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181914 UNC7242 Antagonist / Unkown
HY-RS08766 MTF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22243 Mtf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28765 Mtf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtf2 NCBI NCBI:22823