Mthfd2 - methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Gene

Also Known as NMDMC

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17768

Summary

Predicted to enable several functions, including magnesium ion binding activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to act upstream of or within one-carbon metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Mthfd2 Products (1)

mRNA Protein Name
NM_008638.2 NP_032664.1 bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables methenyltetrahydrofolate cyclohydrolase activity IDA
IDA: Inferred from direct assay
2647744 MGI
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
2647744 MGI
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
2647744 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-155950 TH9619 99.33% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130251 DS18561882 99.95% Unkown
HY-101943 LY 345899 98.0% Unkown
HY-131943 DS44960156 Inhibitor ≥99.0% Unkown
HY-155219 TH9028 / Unkown
HY-149825 MTHFD2-IN-1 Inhibitor / Unkown
HY-149826 MTHFD2-IN-2 Inhibitor / Unkown
HY-149827 MTHFD2-IN-3 Inhibitor / Unkown
HY-149828 MTHFD2-IN-4 Inhibitor / Unkown
HY-149828A MTHFD2-IN-4 sodium Inhibitor / Unkown
HY-170361 MTHFD2-IN-5 Inhibitor / Unkown
HY-172910 MTHFD2-IN-6 / Unkown
HY-182284 Anticancer agent 310 / Unkown
HY-182355 MTHFD2-IN-7 Inhibitor / Unkown
HY-182356 MTHFD1/2-IN-1 Inhibitor / Unkown
HY-183364 MTHFD2-IN-8 / Unkown
HY-RS08776 MTHFD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08777 MTHFD2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148014 TH7299 / Unkown
HY-RS16648 Mthfd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23082 Mthfd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mthfd2 NCBI NCBI:10797