Myo1c - myosin IC Gene

Also Known as NMI; MMIb; myr2; MYO1E; mm1beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17913

Summary

This gene encodes a member of the unconventional Myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Myo1c Products (4)

mRNA Protein Name
NM_001080774.2 NP_001074243.1 unconventional myosin-Ic isoform b
NM_001080775.2 NP_001074244.1 unconventional myosin-Ic isoform a
NM_001370611.2 NP_001357540.1 unconventional myosin-Ic isoform c
NM_008659.4 NP_032685.1 unconventional myosin-Ic isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables microfilament motor activity EXP
EXP: Inferred from Experiment
19046570 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15976448 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
19144319 MGI
acts upstream of or within positive regulation of cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
12490950 MGI
acts upstream of or within positive regulation of cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
12490950 MGI
acts upstream of or within positive regulation of protein targeting to membrane IDA
IDA: Inferred from direct assay
12490950 MGI
acts upstream of or within positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
12490950 MGI
acts upstream of or within vesicle transport along actin filament IDA
IDA: Inferred from direct assay
12490950 MGI
Cellular Component GO Annotation Evidence Références Source
located in brush border IDA
IDA: Inferred from direct assay
15758024 MGI
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
12490950 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
19144319 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12490950 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
17050716 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-Ic

  • MMI-beta

  • myosin I beta

  • myosin-Ibeta

  • myosin-Ic

  • nuclear myosin I beta

Myo1c Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Myo1c Q9WTI7 Plekhb1 Mus musculus Q9QYE9-1
Anti Tag CoIP
15976448
Intra
Myo1c Q9WTI7 Plekhb1 Mus musculus Q9QYE9-1
Pull Down
15976448
Intra
Myo1c Q9WTI7 Plekhb1 Mus musculus Q9QYE9-2
Y2H
15976448
Intra
Myo1c Q9WTI7 Plekhb1 Mus musculus Q9QYE9-2
Pull Down
15976448
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08939 MYO1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08941 MYO1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21659 Myo1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28177 Myo1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo1c NCBI NCBI:4641