Myoc - myocilin Gene

Also Known as TIGR; GLC1A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17926

Summary

Enables receptor tyrosine kinase binding activity. Involved in several processes, including ERBB2-ERBB3 signaling pathway; neurogenesis; and skeletal muscle hypertrophy. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and node of Ranvier. Is expressed in several structures, including brain; eye; genitourinary system; lung; and meninges. Used to study open-angle glaucoma. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin). [provided by Alliance of Genome Resources, Apr 2022]

Myoc Products (1)

mRNA Protein Name
NM_010865.3 NP_034995.3 myocilin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12019210 MGI
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
23897819 MGI
Biological Process GO Annotation Evidence References Source
involved in ERBB2-ERBB3 signaling pathway IDA
IDA: Inferred from direct assay
23897819 MGI
involved in bone development IDA
IDA: Inferred from direct assay
23629661 MGI
involved in clustering of voltage-gated sodium channels IMP
IMP: Inferred from mutant phenotype
23897819 MGI
involved in myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
23897819 MGI
involved in osteoblast differentiation IDA
IDA: Inferred from direct assay
23629661 MGI
involved in skeletal muscle hypertrophy IDA
IDA: Inferred from direct assay
22371502 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
23629661 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23629661 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12019210 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
23897819 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myocilin

  • trabecular meshwork-induced glucocorticoid response protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08954 MYOC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20300 Myoc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26808 Myoc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myoc NCBI NCBI:4653