Myog - myogenin Gene

Also Known as myo; MYF4; bHLHc3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17928

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of cell differentiation; and regulation of muscle adaptation. Acts upstream of or within several processes, including cellular response to lithium ion; cellular response to tumor necrosis factor; and skeletal muscle fiber development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and musculature. Orthologous to human MYOG (myogenin). [provided by Alliance of Genome Resources, Apr 2022]

Myog Products (1)

mRNA Protein Name
NM_031189.2 NP_112466.1 myogenin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity IDA
IDA: Inferred from direct assay
15706034 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17531403 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12486129 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
15706034 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10835421 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19783823 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
22847234 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20399744 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7973707 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22638570 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to estradiol stimulus IDA
IDA: Inferred from direct assay
15706034 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
15322112 MGI
acts upstream of or within cellular response to lithium ion IDA
IDA: Inferred from direct assay
15673614 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
24349514 MGI
involved in muscle cell differentiation IDA
IDA: Inferred from direct assay
10652346 MGI
acts upstream of or within muscle organ development IGI
IGI: Inferred from genetic interaction
8587605 MGI
acts upstream of or within myotube differentiation IGI
IGI: Inferred from genetic interaction
22106411 MGI
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
22847234 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
8587605 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17904117 MGI
involved in positive regulation of muscle atrophy IMP
IMP: Inferred from mutant phenotype
21465538 MGI
involved in positive regulation of myoblast differentiation IDA
IDA: Inferred from direct assay
22847234 MGI
involved in positive regulation of myotube differentiation IDA
IDA: Inferred from direct assay
22847234 MGI
involved in positive regulation of skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
8393145 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8760303 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15706034 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20399744 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22638570 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8393145 MGI
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
22847234 MGI
involved in regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
21465538 MGI
involved in regulation of skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
21465538 MGI
involved in response to denervation involved in regulation of muscle adaptation IDA
IDA: Inferred from direct assay
21465538 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
8393145 MGI
acts upstream of or within skeletal muscle tissue development IDA
IDA: Inferred from direct assay
14762206 MGI
involved in striated muscle atrophy IMP
IMP: Inferred from mutant phenotype
21465538 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16554364 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myogenin

  • MYOD1-related protein

Myog Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Myog P12979 Mef2a Mus musculus Q60929
Anti Bait CoIP
7973707
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W021448 Glycocyamine 99.96% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W021448S Glycocyamine-d2 99.90% Unkown
HY-W021448S1 Glycocyamine-15N,13C2 97.40% Unkown
HY-RS08959 MYOG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W754199 Glycocyamine-13C / Unkown
HY-RS20301 Myog Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26809 Myog Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myog NCBI NCBI:4656