Ncl - nucleolin Gene

Also Known as C23; Nucl; D0Nds28; D1Nds28; B530004O11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17975

Summary

Enables RNA binding activity. Acts upstream of or within cellular response to epidermal growth factor stimulus; cellular response to leukemia inhibitory factor; and positive regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Is expressed in several structures, including 1st branchial arch mandibular component; blastocyst; central nervous system; early embryo; and tooth. Orthologous to human NCL (nucleolin). [provided by Alliance of Genome Resources, Apr 2022]

Ncl Products (1)

mRNA Protein Name
NM_010880.3 NP_035010.3 nucleolin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PH domain binding IPI
IPI: Inferred from physical interaction
9813005 MGI
enables RNA binding IDA
IDA: Inferred from direct assay
17971306 MGI
enables insulin receptor substrate binding IPI
IPI: Inferred from physical interaction
9813005 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10567518 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
8702723 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
9813005 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24530304 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
9813005 MGI
Cellular Component GO Annotation Evidence References Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
2100262 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
17971306 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9102301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleolin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-174346 Skp2-IN-4 98.60% Unkown
HY-12645 NCL1 Inhibitor / Unkown
HY-178048 Neuroprotective agent 13 Activator / Unkown
HY-178052 Neuroprotective agent 14 Activator / Unkown
HY-RS03886 DNAJC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09086 NCL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P5551 TLN-58 Inhibitor / Unkown
HY-RS17936 Ncl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24407 Ncl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncl NCBI NCBI:4691