Ndrg1 - N-myc downstream regulated gene 1 Gene

Also Known as RTP; DRG1; NMSL; Ndr1; Ndrl; TDD5; CAP43; CMT4D; HMSNL; PROXY1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17988

Summary

Predicted to enable Cadherin binding activity; small GTPase binding activity; and tubulin binding activity. Involved in negative regulation of cell population proliferation and peripheral nervous system myelin maintenance. Acts upstream of or within mast cell activation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study Charcot-Marie-Tooth disease type 4D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1). [provided by Alliance of Genome Resources, Apr 2022]

Ndrg1 Products (1)

mRNA Protein Name
NM_008681.2 NP_032707.2 protein NDRG1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within mast cell activation IDA
IDA: Inferred from direct assay
12804568 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23555679 MGI
involved in peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
15082788 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15082788 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein NDRG1

  • N-myc downstream regulated 1

  • N-myc downstream-regulated gene 1 protein

  • protein Ndr1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145723B MAX-40279 hemifumarate Inhibitor 99.52% Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125878 PROTAC SGK3 degrader-1 Inhibitor 99.89% Unkown
HY-145723 MAX-40279 Inhibitor 97.04% Unkown
HY-15193B EMD638683 (S-Form) Inhibitor 99.72% Unkown
HY-RS17382 Ndrg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145723C MAX-40279 hemiadipate Inhibitor 99.26% Unkown
HY-145723A MAX-40279 hydrochloride Inhibitor / Unkown
HY-151009 308-R Inhibitor / Unkown
HY-RS09114 NDRG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23837 Ndrg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndrg1 NCBI NCBI:10397