AGRP - agouti related neuropeptide Gene

Also Known as ART; AGRT; ASIP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 181

About AGRP

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,482,571-67,483,547 (from NCBI)

This gene has 1 transcript (splice variant), 179 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in adrenal (RPKM 1.6), lung (RPKM 0.8) and 5 other tissues.

Summary

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via Melanocortin Receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

AGRP Products (1)

mRNA Protein Name
NM_001138.2 NP_001129.1 agouti-related protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropeptide hormone activity IDA
IDA: Inferred from direct assay
15927146 GOA
Biological Process GO Annotation Evidence References Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
15927146 GOA
involved in regulation of feeding behavior IDA
IDA: Inferred from direct assay
15927146 GOA
involved in regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
9311920 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi lumen IDA
IDA: Inferred from direct assay
15927146 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
15927146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGRP Protein Structure

Agouti

Agouti: Agouti protein (33 - 122)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

agouti-related protein

  • agouti related protein homolog

Recombinant AGRP Proteins

Cat. No. Product Name Accession Purity
HY-P75526 AGRP Protein, Human (HEK293, His) O00253 (A21-T132) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75527 AGRP Protein, Human (48a.a, HEK293, Fc) O00253 (S83-T132) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P75528 AGRP Protein, Human (HEK293, Fc) O00253 (A21-T132) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Anorexia Nervosa

  • Anorexia Nervosa, Susceptibility To

  • ANON

  • Anorexia Nervosa, Susceptibility To, 1

  • An

  • Anorexia Nervosa 1

  • An - [Anorexia Nervosa]
Overnutrition
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Leptin Deficiency Or Dysfunction

  • Morbid Obesity

  • Obesity Due To Congenital Leptin Deficiency

  • LEPD

  • Congenital Leptin Deficiency

  • Obesity, Morbid

  • Obesity, Morbid, Due To Leptin Deficiency

  • Severe Obesity

  • Obesity, Morbid, Nonsyndromic 1

  • Leptin Deficiency

  • Obesity, Severe, Due To Leptin Deficiency

  • Leptin

  • Morbid Obesity Due To Leptin Deficiency

  • Obesity Morbid

  • Leptin Dysfunction
Eating Disorder

  • Eating Disorders

  • Feeding And Eating Disorders
Acquired Metabolic Disease
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116797 MS15203 99.40% Unkown
HY-P3561A Agouti-related Protein (AGRP) (83-132) Amide (human) TFA Inhibitor 98.30% Unkown
HY-P3561 Agouti-related Protein (AGRP) (83-132) Amide (human) Antagonist / Unkown
HY-P3924 Agouti-Related Protein (54-82) (human) Inhibitor / Unkown
HY-RS00465 AGRP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17733 Agrp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24198 Agrp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AGRP RGD RGD:2068
Macaca mulatta AGRP VGNC VGNC:104680
Bos taurus AGRP VGNC VGNC:25743
Mus musculus AGRP MGD MGI:892013
Canis familiaris AGRP VGNC VGNC:37717
Others AGRP NCBI