Notch3 - notch 3 Gene

Also Known as N3; hpbk

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18131

Summary

Enables enzyme binding activity. Involved in Notch signaling pathway and positive regulation of smooth muscle cell proliferation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study CADASIL 1 and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (Notch receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Notch3 Products (1)

mRNA	Protein	Name
NM_008716.3	NP_032742.1	neurogenic locus notch homolog protein 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17573339	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9111338	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	19855400	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23117660	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	16120638	MGI
involved in glomerular capillary formation	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23117660	MGI
acts upstream of neuroblast differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	16120638	MGI
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	19855400	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23117660	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	21191019	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17079689	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neurogenic locus notch homolog protein 3

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15670	BMS-906024	Inhibitor	99.91%	Phase 1
HY-12860	BMS-986115	Inhibitor	99.90%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99320	Tarextumab	Inhibitor	99.83%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15827	NSC 405020	Inhibitor	99.63%	Unkown
HY-136522	S2116		98.05%	Unkown
HY-RS09451	NOTCH3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-136523	S2157		98.44%	Unkown
HY-RS17213	Notch3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23665	Notch3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992438	PF-06650808 Antibidy	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Notch3	NCBI	NCBI:4854